Epidemiology
mostly sporadic
rare familial occurence (11115185)
Microscopical synopsis
biphasic growth pattern
dilated vascular structures in the superficial dermis lined by prominent hobnail endothelial cells
collagen dissecting, rather narrow neoplastic vessels in deeper parts of the lesion
Immunochemistry
CD31 + (100%) (10472756)
CD34 +/- (8%) (10472756)
VEGFR-3 (50%) (10472756)
D2-40+
Differential diagnosis
cavernous lymphangioma
lymphangioma circumscriptum
retiform hemangioendothelioma
progressive lymphangioma
Dabska’s tumor
See also
vascular tumors
References
Franke FE, Steger K, Marks A, Kutzner H, Mentzel T. Hobnail hemangiomas (targetoid hemosiderotic hemangiomas) are true lymphangiomas. J Cutan Pathol. 2004 May;31(5):362-7. PMID: 15059220
