Underexpressed in tumors

Articles

• CHFR
  3 April 2005

  A number of human cancers are sensitive to mitotic stress, implying checkpoint defects. Many proteins that contain forkhead-associated (FHA) domains are cell cycle checkpoints.
  Animal models
  CHFR null mice (#15793587#)
  Pathology
  Expression of the mitotic checkpoint protein Chfr is lost in 20-50% of primary tumors and tumor cell lines.

• SLIT2
  21 September 2004

  Functions
  Slit2 plays a vital role in axon guidance by signaling through Robo receptors (ROBOs), like ROBO1.
  Slit2 has been shown to inhibit leukocyte chemotaxis.
  SLIT2 protein is a putative ligand for the ROBO receptors.
  Pathology
  SLIT2 is frequently inactivated by promoter region hypermethylation and allele loss in pulmonary carcinomas and mammary carcinomas (#12384551#) Promoter hypermethylation has been shown to be a common mechanism for inactivation of tumor suppressor genes (...)

• NKX3A
  31 January 2007

  NKX3-1
  Definition: The homeodomain-containing transcription factor NKX3A is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner.
  NKX3.1 is a prostatic tumor suppressor gene located on chromosome 8p.
  Although most studies have shown that staining for NKX3.1 protein is positive in the majority of primary prostatic adenocarcinomas, it has been shown to be downregulated in many high-grade prostate cancers, and completely lost in (...)

• TUSC4
  31 January 2007

  NPRL2 is one of the novel candidate tumor suppressor genes identified in the human chromosome 3p21.3 region. The NPRL2 has shown potent tumor suppression activity in vitro and in vivo and has been suggested to be involved in DNA mismatch repair, cell cycle checkpoint signaling, and regulation of the apoptotic pathway.
  Tumors
  non-small-cell lung cancer (#17018626#) squamous cell bronchial carcinoma
  References
  Ueda K, Kawashima H, Ohtani S, Deng WG, Ravoori M, Bankson J, Gao B, Girard (...)

• CABLES1
  5 June 2007

  CDK5 and ABL enzyme substrate 1

• CASR
  17 March 2011

  Pathology
  Ca(2+) is a chemopreventive agent for colon cancer.
  Ion transport systems are often altered in human cancer.
  CpG islands are densely methylated in cancer cell lines with reduced CASR mRNA expression.
  Treatment with a demethylating agent, 5-aza-2’-deoxycytidine, and/or a histone deacetylase inhibitor, trichostatin A, restores CASR expression in the cancer cell lines.
  Disruption of CASR expression in CASR-unmethylated HCT-8 cells blocsd the enhancing effect of Ca(2+) on the (...)