Molecular medicine

Articles

• ribosomopathies
  30 March 2010

  Ribosomopathies comprise a collection of disorders in which genetic abnormalities cause impaired ribosome biogenesis and function, resulting in specific clinical phenotypes.
  Congenital mutations in RPS19 and other genes encoding ribosomal proteins cause Diamond-Blackfan anemia, a disorder characterized by hypoplastic, macrocytic anemia.
  Mutations in other genes required for normal ribosome biogenesis have been implicated in other rare congenital syndromes:
  Shwachman-Diamond syndrome (...)

• genomic instability
  13 July 2003

  genetic instability; genome instability
  Definition: Genomic instability is considered as a significant factor in the pathogenesis of cancer.
  There are several patterns of genomic instability, which are reflections of different functional defects in the cancer cells.
  Genomic instability can be divided into 2 categories: Retour ligne manuel
  chromosomal instability (CIN) Retour ligne manuel
  microsatellite instability (MSI).
  Genetic alterations can affect the structure of chromosomes, (...)

• molecular lesions
  11 March 2006

  A molecular lesion is damage to the structure of a molecule that results in reduction or absence of normal function. Pertains to biological molecules such as DNA, enzymes, and proteins.
  Types
  DNA lesions (DNA damage)
  protein lesions
  lipid lesions
  See also
  Lesions

• protein kinases
  3 December 2003

  kinases, kinase

• molecular psychiatry
  16 June 2003

  References
  Gray L, Hannan AJ. Dissecting cause and effect in the pathogenesis of psychiatric disorders: genes, environment and behaviour. Curr Mol Med. 2007 Aug;7(5):470-8. PMID: #17691962#
  Lehrmann E, Hyde TM, Vawter MP, Becker KG, Kleinman JE, Freed WJ. The use of microarrays to characterize neuropsychiatric disorders: postmortem studies of substance abuse and schizophrenia. Curr Mol Med. 2003 Aug;3(5):437-46. PMID: #12942997#
  Voshol H, Glucksman MJ, van Oostrum J. Proteomics in the (...)

• paternal-age effect
  22 September 2003

  Features
  The paternal-age effect in Apert’s Syndrome is due, in part, to the increased frequency of mutations in Sperm (#12900791#).

• molecular infectiology
  6 March 2004

  Books
  Molecular Infection Biology: Interactions Between Microorganisms and Cells. by Jörg Hacker (Editor), Jürgen Heesemann (Editor). Hardcover: 339 pages ; Dimensions (in inches): 0.84 x 10.38 x 7.06. Publisher: Wiley-Spektrum; 1st edition (October 2002). ISBN: 0471178462
  Cellular Microbiology : Bacteria-Host Interactions in Health and Disease. by Brian Henderson, Michael F. Wilson, Rod McNab, Alistair J. Lax. Paperback: 478 pages ; Dimensions (in inches): 1.11 x 9.74 x 7.48. Publisher: (...)

• disease-predisposing mutations
  1 October 2003

  References
  Steward RE, MacArthur MW, Laskowski RA, Thornton JM. Molecular basis of inherited diseases : a structural perspective. Trends Genet. 2003 Sep ;19(9):505-13. PMID : #12957544#

• molecular angiology
  3 October 2003

  References
  Towbin JA, Casey B, Belmont J. The molecular basis of vascular disorders. Am J Hum Genet. 1999 Mar;64(3):678-84. PMID: #10053000#

• molecular hepatology
  6 March 2004

  anomalies of bile metabolism
  PFIC
  cirrhosis
  hepatic fibrosis
  viral hepatitis

0 | 10 | 20 | 30 | 40