Protein family

Articles

• RGKs
  19 January 2006

  RGK proteins (RGKs) are small Ras-related GTP-binding proteins that function as potent inhibitors of voltage-dependent calcium channels, and two members of the family, Gem and Rad, modulate Rho-dependent remodeling of the cytoskeleton.
  Within the Ras superfamily, RGK proteins have distinct structural and regulatory characteristics. It is an open question as to whether RGK proteins catalyze GTP hydrolysis in vivo. Binding of calmodulin and the 14-3-3 protein to RGK proteins controls (...)

• MSXs
  26 May 2004

  Vertebrate Msx genes are unlinked, homeobox-containing genes that bear homology to the Drosophila muscle segment homeobox gene.
  Members MSX1 MSX2
  MSXs genes are expressed at multiple sites of tissue-tissue interactions during vertebrate embryonic development.
  Inductive interactions mediated by the MSXs genes are essential for normal craniofacial, limb and ectodermal organ morphogenesis, and are also essential to survival in mice, as manifested by the phenotypic abnormalities shown (...)

• IRAKs
  30 May 2007

  interleukin-1 receptor associated kinases.

• EXTs
  26 June 2007

  Members EXT1 EXT2
  References
  Signori E, Massi E, Matera MG, Poscente M, Gravina C, Falcone G, Rosa MA, Rinaldi M, Wuyts W, Seripa D, Dallapiccola B, Fazio VM. A combined analytical approach reveals novel EXT1/2 gene mutations in a large cohort of Italian multiple osteochondromas patients. Genes Chromosomes Cancer. 2007 May;46(5):470-7. PMID: #17301954#

• CDC25s
  2 July 2007

  Members: CDC25A, CDC25B, CDC25C
  Functions
  Cell division cycle 25 phosphatases (CDC25s) regulate key transitions between cell cycle phases during normal cell division, and in the event of DNA damage they are key targets of the checkpoint machinery that ensures genetic stability.
  Pathology
  CDC25s proteins overexpression has been reported in a significant number of human cancers.
  References
  Boutros R, Lobjois V, Ducommun B. CDC25 phosphatases in cancer cells: key players? Good targets? (...)

• p53 family
  5 July 2007

  The role of p53 as a tumour suppressor is generally attributed to its ability to stop the proliferation of precancerous cells by inducing cell-cycle arrest or apoptosis.
  The relatives and evolutionary predecessors of p53 (TP53), p63 (TP73L) and p73 (TP573), share the tumour-suppressor activity of p53 to some extent, but also have essential functions in embryonic development and differentiation control.
  These ancestral functions in differentiation control contribute to the (...)

• ACVRs
  24 July 2007

  Members ACVR1A ACVR1B ACVR2A ACVR2B

• TET proteins
  18 June 2007

  Fusions of the TET-proteins (TLS/FUS, EWSR1, and TAF15/RBP56) to different transcription factors are involved in various malignancies including Ewing’s sarcoma, primitive neuroectodermal tumors, and acute myeloid leukemia.
  These are thought to arise through transcriptional deregulation, with the transcription factor defining the tumor phenotype.
  Members
  FUS (TLS)
  EWSR1
  TAF15 (RBP56) (MIM.601574)
  See also (...)

• DVLs
  14 February 2006

  dishevelled proteins (DVLs)

• NRPs
  24 November 2006

  Neuropilins

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