Cancer gene

Articles

• GLI1
  28 June 2004

  Ci, Cubitus interruptus homolog GLI1, glioma-associated oncogen homolog GLI, GLI
  Definition: GLI is a Zinc Finger transcription factor that is the transcription factor of the Hedgehog signaling pathway.
  Gli code hypothesis (#17845852#)
  The Gli code hypothesis postulates that the three vertebrate Gli transcription factors act together in responding cells to integrate intercellular Hedgehog (Hh) and other signaling inputs, resulting in the regulation of tissue pattern, size and shape.
  Hh (...)

• YEATS4
  30 September 2008

  Definition: YEATS4 is a transcription factor.
  Shown to inhibit p53 transactivation activity and decrease the p53 proapoptotic response, the inhibition of YEATS4 results in p53 stabilization and activation.
  Pathology
  YEATS4 is a transcription factor amplified in human gliomas.
  YEATS4 (GAS41) as a novel oncogene important in the pathogenesis of WDLPS/DDLPS (well-differentiared liposarcoma/dedifferentiated liposarcoma).
  The functional impairment of the p53 pathway plays a crucial role (...)

• ETV6
  3 June 2004

  TEL (translocation ets leukemia)

• ERBB2
  11 February 2006

  ERBB2 ; CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1; c-erbb2
  The oncogene originally called HER/NEU was derived from rat neuro/glioblastoma cell lines. It encodes a tumor antigen, p185, which is serologically related to EGFR, the epidermal growth factor receptor (MIM.131550).
  ERBB2 encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases (ERBBs).
  ERBB2 has no ligand binding domain of its own and therefore cannot bind growth factors. (...)

• STK11
  29 October 2003

  XEEK1, LKB1
  Definition: STK11 (LKB1) is a serine-threonine protein kinase mutated in patients with an autosomal dominantly inherited cancer syndrome predisposing to multiple benign and malignant tumours, termed Peutz-Jeghers syndrome.
  LKB1 has been implicated as a regulator of multiple biological processes and signaling pathways, including the control of cell-cycle arrest, p53-mediated apoptosis, Wnt signaling, transforming growth factor (TGF)-beta signaling, ras-induced cell (...)

• CHEK2
  26 September 2003

  CHK2 is an important multifunctional player in the DNA-damage response signalling pathway. Parallel studies of the human CHEK2 gene have also highlighted its role as a candidate multiorgan tumour susceptibility gene rather than a highly penetrant predisposition gene for Li-Fraumeni syndrome.
  The cell cycle checkpoint kinase CHEK2 is a protein kinase activated in response to DNA damage, is involved in cell cycle arrest. CHEK2 is the upstream regulator of p53 in the DNA-damage-signaling (...)

• GAB2
  14 September 2007

  Chromosome arm 11q amplifications involving the mixed lineage leukemia gene (MLL) locus are rare but recurrent aberrations in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). GAB2 is a novel target of 11q amplification in AML/MDS.
  In addition to the MLL core amplicon, independent sequences in 11q23-24 and/or 11q13.5 are coamplified within the same cytogenetic markers in 90% and 60% of patients, respectively.
  The minimal amplicon in 11q13.5 measures 1.17 Mb.
  Pathology
  The (...)

• CD44
  17 June 2003

  Definition: CD44 is a well characterized cellular adhesion molecule involved in several human malignancies. It is encoded by a gene located at 11p12-13.
  Functions
  CD44 binds hyaluronan. Mucin-like glycoproteins, such as heparan sulfate, serve as ligands for the leukocyte adhesion molecule called CD44. These glycoproteins are found in the extracellular matrix and on cell surfaces.
  CD44 is expressed by lymphoid cells, and is involved in the extravasation of lymphoid cells, it does not (...)

• NKX3A
  31 January 2007

  NKX3-1
  Definition: The homeodomain-containing transcription factor NKX3A is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner.
  NKX3.1 is a prostatic tumor suppressor gene located on chromosome 8p.
  Although most studies have shown that staining for NKX3.1 protein is positive in the majority of primary prostatic adenocarcinomas, it has been shown to be downregulated in many high-grade prostate cancers, and completely lost in (...)

• PAX8
  5 July 2004

  PO
  Definition: PAX8 is a paired-box gene important in embryogenesis of the thyroid, Müllerian tract, and renal/upper urinary tracts.
  Images
  FNA of extraovarian primary peritoneal carcinoma metastatic to supraclavicular lymphnode ER+ PAX8+ https://twitter.com/pathologyfinder/status/768395560562876416
  Function
  Pax8 is a transcription factor associated with the embryonic development of the thyroid gland, kidney, and the Müllerian system and plays a role in the tumorigenesis of these (...)

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