Cancer gene

Articles

• CDKN1A
  29 November 2003

  p21, WAF1: CDKN1
  CDK-INTERACTING PROTEIN 1; CIP1
  WILDTYPE p53-ACTIVATED FRAGMENT 1; WAF1
  p21

• CD44
  17 June 2003

  Definition: CD44 is a well characterized cellular adhesion molecule involved in several human malignancies. It is encoded by a gene located at 11p12-13.
  Functions
  CD44 binds hyaluronan. Mucin-like glycoproteins, such as heparan sulfate, serve as ligands for the leukocyte adhesion molecule called CD44. These glycoproteins are found in the extracellular matrix and on cell surfaces.
  CD44 is expressed by lymphoid cells, and is involved in the extravasation of lymphoid cells, it does not (...)

• ATM
  28 October 2003

  ataxia-telangiectasia mutated

• HMGA2
  27 October 2004

  HMGI-C, HMGI-C

• ALK
  19 June 2003

  Locus: 2p23. AGCOH OMIM
  Cytogenetics
  t(2;17)(p23;q23)
  Pathology
  ALK rearrangements - ALK fusion
  Chromosomal rearrangements involving the anaplastic lymphoma kinase gene (ALK) at 2p23 result in fusion with various partner genes leading to aberrant production of oncogenic protein products in multiple tumor types.
  In tumorigenesis, the ALK gene at 2p23 is known to be fused to NPM, TPM3, TPM4, TFG, ATIC, CLTC, MSN, and ALO17.
  ALK-ATIC by inv(2)(p23q35) in IMF (#12939746#) (...)

• NTRK3
  3 June 2004

  TrkC; TRKC
  Definition: TrkC is a member of the Trk family of tyrosine kinase receptors and plays an important role in the development and maintenance of neural tissues.
  Pathology
  ETV6-NTRK3 fusion gene by translocation t(12;15)(p13;q25) congenital fibrosarcoma (#9462753#) mesoblastic nephroma (#9811336#, #9823307#) chronic myeloid leukemia secretory breast carcinoma (#15101049#)
  NTRK3 signaling is activated in adenoid cystic carcinoma and requires NT-3 to stimulate invasive (...)

• ERBB4
  11 October 2011

  HER4

• KIT
  12 December 2003

  c-kit; CD117
  Definition: The proto-oncogene c-kit / CC117 is a receptor tyrosine kinase recognized to initiate essential signal transduction pathways that transmit biological signals for cellular proliferation, differentiation, and metastasis. Aberrant expression or mutation of c-kit has been shown to be involved in the pathogenesis of many cancers. See also CD117 IHCDB
  Expression in cells
  c-KIT positive spermatogonia
  Expression in tumors (Exemples)
  chromophobe renal cell (...)

• ESR1
  12 December 2003

  ER-alpha, estrogen receptor alpha

• MAML2
  8 March 2004

  Mastermind-like Notch coactivator MAML2
  Pathology
  MAML2-MECT1 (MAMl2-CRTC1) gene fusion by t(11;19)(q21;p13) in
  mucoepidermoid carcinoma (#14720503#)
  benign Warthin tumor (#14720503#)
  cutaneous clear cell hidradenoma (#15729701#, #17334997#)
  MAML2-WAMTP1 gene fusion
  MAML2-MLL gene fusion in
  secondary acute myelogenous leukemia (#17551948#)
  myelodysplastic syndrome with inv(11)(q21q23) (#17551948#)
  The MECT1-MAML2 translocation is identified in a large proportion of (...)

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