Cancer gene

Articles

• PML
  16 March 2004

  Definition: PML is a tumour suppressor inactivated in acute promyelocytic leukemia (APL).
  Function
  PML is the essential component of a subnuclear structure called the PML nuclear body (PML-NB), which is disrupted in APL.
  The promyelocytic leukaemia (PML) tumour suppressor protein epitomizes the PML-nuclear body (PML-NB) and is crucially required for the proper assembly of this macromolecular nuclear structure.
  Unlike other, more specialized subnuclear structures such as Cajal and (...)

• EMS1
  31 January 2007

  cortactin,

• WWOX
  27 February 2007

  Common fragile site gene WWOX encodes a candidate tumor suppressor WW domain-containing oxidoreductase.
  Alteration of this gene, along with dramatic downregulation of WWOX protein, is shown in the majority of invasive cancer cells.
  Ectopic WWOX exhibits proapoptotic and tumor inhibitory functions in vitro and in vivo, probably interacting with growth regulatory proteins p53, p73 and others.
  Hyaluronidases regulate WWOX expression, increase cancer invasiveness and seem to be involved in (...)

• NTRK3
  3 June 2004

  TrkC; TRKC
  Definition: TrkC is a member of the Trk family of tyrosine kinase receptors and plays an important role in the development and maintenance of neural tissues.
  Pathology
  ETV6-NTRK3 fusion gene by translocation t(12;15)(p13;q25)
  congenital fibrosarcoma (#9462753#)
  mesoblastic nephroma (#9811336#, #9823307#)
  chronic myeloid leukemia
  secretory breast carcinoma (#15101049#)
  NTRK3 signaling is activated in adenoid cystic carcinoma and requires NT-3 to stimulate invasive (...)

• BMPR1A
  18 November 2003

  ALK3, ACVRLK3

• TFEB
  20 May 2004

  Molecular biology
  TFEB/MALAT1 fusion gene by t(6;11)(p21;q13) in
  TFEB-associated renal cell carcinoma (#15644781#, #12719541#, #12837690#)
  HMB45+ renal epithelial tumor (#11395386#)
  References
  Argani P, Lae M, Hutchinson B, Reuter VE, Collins MH, Perentesis J, Tomaszewski JE, Brooks JS, Acs G, Bridge JA, Vargas SO, Davis IJ, Fisher DE, Ladanyi M. Renal carcinomas with the t(6;11)(p21;q12): clinicopathologic features and demonstration of the specific alpha-TFEB gene fusion by (...)

• BRD4
  4 December 2009

  bromodomain containing 4

• MLH1
  29 September 2003

  mismatch repair gene
  MLH is homologous to the E. coli MutL gene and is involved in DNA mismatch repair. Mutations in the MLH1 gene result in hereditary nonpolyposis colorectal cancer-2 (HNPCC2) (MIM.609310).
  Pathology
  Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant cancer predisposition syndrome caused by inherited germ line mutations in DNA mismatch repair genes, predominantly MSH2 and MLH1.
  MLH1 loss of expression (...)

• HMGA2
  27 October 2004

  HMGI-C, HMGI-C

• MDM2
  29 October 2003

  mouse double minute 2 homolog, p53 binding protein, HDM2

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