HIKE is a highly conserved sequence motif identified as a candidate pleckstrin-homology (PH) domain binding site in Gbeta proteins, protein kinases, ankyrin and kinesin.
Members
Gbeta proteins
protein kinases
ankyrin
kinesin
gelsolin
neurogranin
neuromodulin
Bruton tyrosin kinase (BTK)
Function
HIKE regions have been demonstrated to bind both proteins and lipids, and to regulate the interaction of Gbeta, neuromodulin and the BTK PH domain with downstream effectors and (...)
Home > Keywords > Proteins > Proteic domains
Proteic domains
Articles
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HIKE
21 November 2003 -
protein interaction domains
30 June 2004Proteins are controlled by a vast and dynamic array of post-translational modifications, many of which create binding sites for specific protein-interaction domains.
These domains, working together, could read the state of the proteome and therefore couple post-translational modifications to cellular organization.
See also
protein domains
References
Seet BT, Dikic I, Zhou MM, Pawson T. Reading protein modifications with interaction domains. Nat Rev Mol Cell Biol. 2006 (...)
