Neurodegenerative disease

Articles

• amyotrophic lateral sclerosis
  23 September 2003

  ALS

• Parkinson disease
  29 September 2003

  Parkinson’s disease, pakinsonism

• multiple system atrophy
  14 April 2009

  While the designation multiple system atrophy (MSA) originally applied to a wide spectrum of neurodegenerative disorders affecting multiple neural "systems," it is now used to describe a group of disorders characterized by the presence of glial cytoplasmic inclusions (GCIs), typically within the cytoplasm of oligodendrocytes.
  With recognition of GCIs, the three clinicopathologic entities of striatonigral degeneration, Shy-Drager syndrome, and olivopontocerebellar atrophy were gathered into (...)

• ataxia telangiectasia
  27 October 2003

  Definition: Ataxia telangiectasia (AT) is another autosomal recessive disorder characterized by cerebellar ataxia, progressive mental retardation, immune defects, severe muscular incoordination, and a strong predisposition to malignancy, particularly in the lymphoreticular system. The term telangiectasia describes the dilatation of blood vessels, particularly in the eyes and skin.
  Patients with this disease have several defects, including hypersensitivity to ionising radiation. Death is (...)

• bulbospinal atrophy
  14 April 2009

  Kennedy syndrome

• Leigh syndrome
  28 May 2003

  Leigh’s syndrome

• Pelizaeus-Merzbacher disease
  28 October 2003

  Pelizaeus-Merzbacher Disease is an X-linked, invariably fatal, leukodystrophy beginning either in early childhood or just after birth, and characterized by slowly progressive signs and symptoms resulting from widespread white matter dysfunction.
  Patients present with pendular eye movements, hypotonia, choreoathetosis, and pyramidal signs early in the disease, followed later by spasticity, dementia, and ataxia.
  The disease has been shown to arise in most cases from defects in a gene on the (...)

• Alzheimer disease
  20 October 2003

  Alzheimer’s disease