Overexpressed in tumors

Articles

• GATA3
  24 May 2005

  GATA-3
  PO
  Definition: GATA3 is a zinc-finger transcription factor (ZFNs), which is expressed in various normal and neoplastic tissues.
  GATA3 is a transcription factor important in the differentiation of breast epithelia, urothelia, and subsets of T-lymphocytes.
  It has been suggested useful in the evaluation of mammary or urothelial origin or metastatic carcinomas. GATA3 is a useful marker in characterization not only mammary carcinomas and urothelial carcinoma but also for renal tumors (...)

• HOXA13
  20 June 2005

  Pathology
  triphalangeal thumb-brachyectrodactyly syndrome (#12382951#)
  hand-foot-genital syndrome
  polyalanine repeat expansion
  HOXA genes in T-cell acute lymphoblastic leukemia (T-ALL)
  HOXA13 rearrangement and surexpression in T-cell acute lymphoblastic leukemia (T-ALL) (#16804919#)
  See also
  polyalanine repeat expansions
  References
  Su X, Drabkin H, Clappier E, Morgado E, Busson M, Romana S, Soulier J, Berger R, Bernard OA, Lavau C. Transforming potential of the T-cell acute (...)

• MDM2
  29 October 2003

  mouse double minute 2 homolog, p53 binding protein, HDM2

• CD44
  17 June 2003

  Definition: CD44 is a well characterized cellular adhesion molecule involved in several human malignancies. It is encoded by a gene located at 11p12-13.
  Functions
  CD44 binds hyaluronan. Mucin-like glycoproteins, such as heparan sulfate, serve as ligands for the leukocyte adhesion molecule called CD44. These glycoproteins are found in the extracellular matrix and on cell surfaces.
  CD44 is expressed by lymphoid cells, and is involved in the extravasation of lymphoid cells, it does not (...)

• CDK4
  21 April 2004

  cyclin-dependent kinase-4

• STIM2
  6 September 2007

  STIM2 is an inhibitor of STIM1 (MIM.605921)-mediated store-operated Ca(2+) (SOC) entry.
  Pathology
  STIM2 is overexpressed in glioblastoma multiforme (#17002787#)
  References
  Ruano Y, Mollejo M, Ribalta T, Fiano C, Camacho FI, Gomez E, de Lope AR, Hernandez-Moneo JL, Martinez P, Melendez B. Identification of novel candidate target genes in amplicons of Glioblastoma multiforme tumors detected by expression and CGH microarray profiling. Mol Cancer. 2006 Sep 26;5:39. PMID: (...)

• KIF14
  6 September 2007

  KIF14 is a member of the kinesin superfamily of microtubule-associated motors (KIFs) that play important roles in intracellular transport and cell division.
  Pathology
  located in 1q32.1 amplification (62%) (positively associated with 6p gain and maybe MYCN gain) (#17099872#)
  KIF14 (kinesin family member 14) is an overexpressed candidate oncogene in the 1q31.3-1q32.1 minimal region of genomic gain in breast cancer cell lines.
  KIF14 overexpression is a negative predictor of grade and (...)

• TNFSF13B
  8 March 2006

  BAFF, BLYS, TALL1, THANK

• PRDM16
  3 September 2007

  MEL1

• TRIO
  11 September 2007

  Structure
  The TRIO protein contains 3 functional domains: a serine/threonine kinase domain and 2 guanine nucleotide exchange factor (GEF) domains for the family of Rho-like GTPases, specific for Rac1 (MIM.602048) and RhoA (MIM.165390). These functional domains suggest that this enzyme may play a key role in several signaling pathways that control cell proliferation.
  Pathology
  Copy number gains and high-level amplifications of the short arm of chromosome 5 are frequently observed in soft (...)

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