Humpath.com - Human pathology

Most recent articles

• pediatric auto-immune gastritis

  27 February

  pediatric non-Helicobacter pylori atrophic gastritis
  Although autoimmune atrophic gastritis is classically a disease of elderly adults, recent studies have described the disease in younger adults, particularly in those with other autoimmune diseases and iron-deficiency anemia. Atrophic gastritis in pediatrics is a rare and possibly underdiagnosed entity.
  References
  Pediatric Non-Helicobacter Pylori Atrophic Gastritis: A Case Series. Pogoriler J, Kamin D, Goldsmith JD. Am J Surg Pathol. (...)

• gastric papillary adenocarcinoma

  27 February

  Papillary adenocarcinoma is another common histologic variant often seen in early gastric carcinoma. It tends to affect older people, occur in the proximal stomach, and is frequently associated with liver metastasis and a higher rate of lymph node involvement. Histologically, it is characterized by epithelial projections scaffolded by a central fibrovascular core.

• gastric micropapillary carcinoma

  27 February

  micropapillary carcinoma of stomach
  Micropapillary carcinoma of stomach is a newly recognized histologic variant characterized by small papillary clusters of tumor cells without a distinct fibrovascular core.
  The micropapillary features are often noted in the deep advancing edge of tumor, surrounded by an empty space mimicking retraction artifact.
  Micropapillary carcinoma of stomach, as its counterpart at other organs, tends to form endolymphatic tumor emboli and metastasize to lymph (...)

• primary hepatic tumors with myxoid change

  27 February

  Mucin production in primary liver neoplasms is typically interpreted as evidence for biliary differentiation. However, it has been observed benign and malignant liver tumors that have abundant extracellular myxoid/mucinous material, yet have only evidence of hepatocellular differentiation.
  Extracellular myxoid/mucinous material in isolation should not be interpreted as cholangiocarcinoma. Furthermore, the unique morphology, the clinical characteristics, and the immunophenotype results (...)

• pulmonary pseudotumors

  27 February

  Pulmonary pseudoneoplasms.
  Types
  inflammatory pseudotumors inflammatory myofibroblastic tumor plasma cell granuloma fibrous pseudo-tumor
  organizing pneumonia
  nodular lymphoid hyperplasia
  apical cap
  round atelectasis
  sclerosin mediastinitis
  hyalinizing granuloma
  Open References
  Pulmonary pseudoneoplasms. Yi E, Aubry MC. Arch Pathol Lab Med. 2010 Mar;134(3):417-26. doi: 10.1043/1543-2165-134.3.417. PMID: (...)

• pulmonary coccidioidomycosis

  27 February

  References
  Cavitary pulmonary coccidioidomycosis: pathologic and clinical correlates of disease. Sobonya RE, Yanes J, Klotz SA. Hum Pathol. 2014 Jan;45(1):153-9. doi:10.1016/j.humpath.2013.08.014 .PMID: #24321524#

• ALK-associated Spitz tumor

  26 February

  ALK-associated Spitz nevus
  Activating kinase fusions have recently been described as early oncogenic events that are mutually exclusive with HRAS and BRAF mutations in Spitz tumors.
  Molecular biology
  NPM1-ALK
  TPR-ALK
  CLIP1-ALK
  GTF3C2-ALK
  high frequency of chromosome 2 aberrations (where ALK resides, 63%)
  chromosome 1p loss (37%)
  In a series (#25602801#), Spitz tumors with ALK fusions demonstrated unique histopathologic features. Clefts and small vesicle-like spaces were (...)

• cutaneous spindle B-cell lymphoma

  26 February

  Cutaneous lymphomas of both B cells and less commonly T cells can exceptionally exhibit spindle-cell morphology.
  Less than 30 spindle-cell B-cell lymphomas of the skin have been described, mostly before the adoption of detailed immunohistochemistry, and thus initially interpreted as variants of diffuse large B-cell lymphoma (DLBCL). Furthermore, some authors suggest that cutaneous spindle-cell B-cell lymphomas (cSCBCLs) may behave more aggressively than their conventional morphologic (...)

• low-grade papillary Schneiderian carcinoma

  25 February

  The sinonasal tract harbors several different types of papillomas, some of which can progress to carcinoma. The most frequent among these are inverted and oncocytic Schneiderian papillomas.
  The rates of progression are somewhat controversial but are approximately 5% to 10% and are almost invariably described in the literature as in situ or invasive squamous cell carcinoma.
  Other carcinoma types, such as mucoepidermoid and sinonasal undifferentiated carcinoma, have also been described. (...)

• p16

  25 February

  See CDKN2A

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