Humpath.com - Human pathology

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• thoracic epithelioid malignant vascular tumor

  23 January

  Malignant thoracic epithelioid vascular tumors are an uncommon and heterogenous group of tumors that include low-grade to intermediate-grade epithelioid hemangioendothelioma (EHE) and high-grade epithelioid angiosarcoma (EAS).
  FISH
  Fluorescence in situ hybridization analysis showed CAMTA1-WWTR1 fusions in 4/7 low-grade and 23/23 intermediate-grade EHE (P 0.001).
  In EAS, CAMTA1 rearrangement was negative in all cases, whereas a WWTR1 complex abnormality was found in 1/5 cases (P 0.001). (...)

• ectopic hepatocellular carcinoma

  23 January

  Ectopic liver is a rare developmental error, mostly diagnosed incidentally. This lesion appears to have an increased potential for the development of hepatoma in the absence of malignancy in the mother liver.
  Open References
  Ectopic hepatocellular carcinomas developed in the chest wall and skull. Nenekidis I, Anagnostakou V, Paralikas I, Kokkori A, Dedeilias P, Zisis C. Asian Cardiovasc Thorac Ann. 2011 Oct;19(5):360-2. doi:10.1177/0218492311419460 . PMID: #22100934# (...)

• crystals with the Maltese cross configuration

  9 January

  Etiology
  talc granulomatosis
  Synopsis
  polarizing microscopy reveals strongly birefringent material of varying shapes and sizes, including anisotropic crystals with the Maltese cross configuration characteristic of starch.
  References
  Fine needle aspiration cytology of talc granulomatosis in a peripheral lymph node in a case of suspected intravenous drug abuse. Housini I, Dabbs DJ, Coyne L. Acta Cytol. 1990 May-Jun;34(3):342-4. PMID: (...)

• talc granuloma

  9 January

  talc granulomas; talc granulomatosis
  Localization
  epitrochlear lymph node
  Synopsis
  numerous granulomatous tissue fragments, histiocytes, lymphocytes and giant cells.
  polarizing microscopy reveals strongly birefringent material of varying shapes and sizes, including anisotropic crystals with the Maltese cross configuration characteristic of starch.
  References
  Fine needle aspiration cytology of talc granulomatosis in a peripheral lymph node in a case of suspected intravenous drug (...)

• testicualr Leydig cell tumor

  9 January

  Leydig cell tumor of the testis
  Digital cases
  HPC:119 : Leydig cell tumor.
  JRC:18782 : Testis intestitial cell tumor
  Leydig cell tumors of the testis are rare and account for a small proportion of testicular neoplasms. Most patients (93%) had a testicular mass.
  Metastasis
  Patients with Leydig cell tumors that metastasized are diagnosed at a mean age of 62 years (range, 39-70 years) compared with 48 years (range, 9-79 years) in patients with non-metastasizing tumors (p = 0.25). (...)

• nodal silicosis

  9 January

  Localization mediastinal lymph node supraclavicular lymph node (#10201057#)
  Synopsis nodules with bi-refringent crystals (#10201057#)
  Etiology
  professional silicosis
  inhalation of a domestic product (#2008999#)

• crystal-storing histiocytosis

  9 January

  Examples
  clofazimine treatment for leprosy (#15282969#, #10632497#)
  lymphoplasmacytic proliferations (#8470760#) pulmonary immunocytoma (#9737249#)
  References
  Intra-abdominal, crystal-storing histiocytosis due to clofazimine in a patient with lepromatous leprosy and concurrent carcinoma of the colon. Pais AV, Pereira S, Garg I, Stephen J, Antony M, Inchara YK. Lepr Rev. 2004 Jun;75(2):171-6. PMID: #15282969#
  Clofazimine-induced crystal-storing histiocytosis producing chronic (...)

• clofazimine-induced histiocytosis

  9 January

  crystal-storing histiocytosis due to clofazimine
  Localization Intra-abdominal, crystal-storing histiocytosis due to clofazimine (#15282969#)
  References
  Intra-abdominal, crystal-storing histiocytosis due to clofazimine in a patient with lepromatous leprosy and concurrent carcinoma of the colon. Pais AV, Pereira S, Garg I, Stephen J, Antony M, Inchara YK. Lepr Rev. 2004 Jun;75(2):171-6. PMID: #15282969#
  Clofazimine-induced crystal-storing histiocytosis producing chronic abdominal pain (...)

• pigmented spindle-cell tumors of the lymph node

  9 January

  Pigmented spindle-cell tumors of the lymph nodes; anthracosilicotic spindle-cell pseudotumor; pigmented spindle-cell tumors of the lymph node
  Pigmented spindle-cell tumors of the lymph nodes have a broad differential diagnosis, including both benign and malignant neoplasms.
  Synopsis
  atypical polygonal cells and atypical spindle cells
  bland nuclear features
  abundant cytoplasmic anthracotic pigment
  To do
  immunohistochemistry melanoma markers histiocyte markers
  Polarization (...)

• anthracosilicotic spindle-cell pseudotumor of lymph node

  9 January

  anthraco-silicotic spindle-cell pseudotumor
  Localization
  mediastinum anthracosilicotic spindle-cell pseudotumor of mediastinal lymph node
  See also
  anthracosilicosis (anthraco-silicosis)
  References
  A case report of anthracosilicotic spindle-cell pseudotumor of mediastinal lymph node: cytologic diagnosis by endoscopic ultrasound-guided fine-needle aspiration. Varghese LR, Stanley MW, Wakely PE Jr, Lucido ML, Mallery S, Bardales RH. Diagn Cytopathol. 2005 Oct;33(4):268-72. PMID: (...)

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