Functional proteic groups

Articles

• growth factor receptors
  21 November 2003

  References
  Leof EB. Growth factor receptor signalling: location, location, location. Trends Cell Biol. 2000 Aug;10(8):343-8. PMID: #10884687#

• RNA-binding proteins
  30 November 2003

  Function
  RNA-binding proteins are involved in various aspects of RNA metabolism such as processing, translational control, stabilization, localization and transport.
  Many of these proteins bind several RNA targets and have multiple functions.
  Feautures
  RNA transport
  RNA localization
  RNA metabolism
  RNA splicing
  References
  Lunde BM, Moore C, Varani G. RNA-binding proteins: modular design for efficient function. Nat Rev Mol Cell Biol. 2007 May 2; PMID: #17473849#
  Musunuru K. (...)

• small GTPases
  30 November 2003

  small GTPases of the Ras superfamily in epithelial biogenesis
  The small GTPases of the Ras superfamily play critical roles in epithelial biogenesis. Many key morphogenetic functions occur when small GTPases act at epithelial junctions, where they mediate an increasingly complex interplay between cell-cell adhesion molecules and fundamental cellular processes, such as cytoskeletal activity, polarity and trafficking.
  Important recent advances in this field include the role of additional (...)

• morphogens
  29 October 2003

  morphogen gradients

• bacterial toxins
  12 November 2003

  References
  Lax AJ. New genotoxin shows diversity of bacterial attack mechanisms. Trends Mol Med. 2007 Jan 16; PMID: #17234453#
  Fasano A. Toxins and the gut: role in human disease. Gut. 2002 May;50 Suppl 3:III9-14. PMID: #11953326#

• MMPs
  29 October 2003

  matrix metalloproteases, matrix metalloproteinases
  Definition: Increased expression of matrix metalloproteinases (MMPs) is associated with nearly every tumor type. Although many studies have shown that MMPs can promote malignancy, recent evidence has revealed that MMPs can play a causative role also in the earliest stages of cancer development.
  MMPs not only compromise cell-cell and cell-substratum adhesion processes that impact genomic surveillance mechanisms but also act directly on (...)

• protein phosphatases
  1 December 2003

  Mitosis exit
  The mitosis-to-interphase transition involves dramatic cellular reorganization from a state that supports chromosome segregation to a state that complies with all functions of an interphase cell.
  This process, termed mitotic exit, depends on the removal of mitotic phosphorylations from a broad range of substrates.
  Mitotic exit regulation involves inactivation of mitotic kinases and activation of counteracting protein phosphatases.
  The key mitotic exit phosphatase in budding (...)

• enzymes
  8 March 2004

  Pathology
  enzyme diseases (enzyme defects)
  Videos

• phospholipases
  27 November 2003
• odorant receptors
  23 November 2003

  References
  Kratz E, Dugas JC, Ngai J. Odorant receptor gene regulation: implications from genomic organization. Trends Genet. 2002 Jan;18(1):29-34. PMID: #11750698#

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