Proteins and lipids to be transported are sorted to specific sites on the donor membrane, or compartment, and transport vesicles bud with the aid of cytosolic complexes of coat proteins.
Vesicles move along cytoskeletal tracks, either microtubules or actin filaments, with the help of motor proteins.
The vesicle is tethered and docked near the target membrane and subsequently fuses with the acceptor bilayer, releasing its contents into the target, or acceptor, compartment.
Vesicular coat (...)
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Functional proteic groups
Articles
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vesicular coat proteins
29 October 2003 -
histone acetyltransferases
23 November 2003HAT complexes
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ribosomal initiating factors
29 August 2005Exemples
EIF2A (eukaryotic translation initiation factor IA) -
ADP-ribosyl cyclases
30 August 2005References
Schuber F, Lund FE. Structure and enzymology of ADP-ribosyl cyclases: conserved enzymes that produce multiple calcium mobilizing metabolites. Curr Mol Med. 2004 May;4(3):249-61. PMID: #15101683#
Potter BV, Walseth TF. Medicinal chemistry and pharmacology of cyclic ADP-ribose. Curr Mol Med. 2004 May;4(3):303-11. PMID: #15101687# -
calcium regulating proteins
6 September 2005Ca++ regulating proteins
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muscarinic receptors
6 September 2005References
Dean B, Bymaster FP, Scarr E. Muscarinic receptors in schizophrenia. Curr Mol Med. 2003 Aug;3(5):419-26. PMID: #12942995# -
calcium channels
30 August 2005calcium pumps
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ERM proteins
6 February 2006ERM proteins (Ezrin-Radixin-Moesin proteins)
Ezrin (VIL2), radixin (RDX) (MIM.179410), and moesin (MSN) (MIM.309845), the so-called ERM proteins (Ezrin-Radixin-Moesin proteins), act as linkers between the plasma membrane and the actin cytoskeleton.
ERM proteins are involved in a variety of cellular functions, such as cell adhesion, cell migration, and the organization of cell surface structures. ERM proteins are highly homologous, both in protein structure and in functional activity, (...) -
enzymes
8 March 2004Pathology
enzyme diseases (enzyme defects)
Videos -
chemokine receptors
8 March 2004Members CCRs CXCRs
Features
chemokine receptor-positive cells
References
Tran PB, Miller RJ. Chemokine receptors: signposts to brain development and disease. Nat Rev Neurosci. 2003 Jun;4(6):444-55. PMID: #12778117#