LKM1-associated autoimmune hepatitis or anti-LKM1 chronic active hepatitis
Definition: Autoimmune hepatitis (AIH) type 2 is identified by the presence in the serum of anti-liver/kidney microsome type 1 autoantibody.
Type 2 AIH, characterized by anti-liver kidney microsomal antibodies. This form is rare in adults.
Anti-liver cytosol autoantibody has been reported in children with autoimmune liver disorders mostly in association with anti-liver/kidney microsome reactivity. However, its (...)
Home > Keywords > Physiopathological pathways > Autoimmune diseases
Autoimmune diseases
Auto-immunity
Articles
-
autoimmune hepatitis type 2
21 February 2006 -
celiac disease
6 April 2004coeliac disease; celiac sprue; gluten-sensitive enteropathy
Definition: Celiac disease is a common autoimmune condition triggered by ingesting one of several related proteins found in wheat, barley, and rye: the gliadins, hordeins, and secalins.
In susceptible persons, ingestion of these proteins leads to infiltration of the intestinal mucosa by both intraepithelial CD8+ lymphocytes and CD4+ lamina propria lymphocytes and, ultimately, to crypt hyperplasia and villous atrophy.
Symptoms (...) -
Hashimoto thyroiditis
12 January 2006Hashimoto’s thyroiditis; Struma lymphomatosa (lymphocytic thyroiditis); chronic lymphocytic thyroiditis, Hashimoto thyroiditis, thyroid autoimmunity
Definition: Hashimoto thyroiditis (or chronic lymphocytic thyroiditis) is the most common cause of hypothyroidism in areas of the world where iodine levels are sufficient. It is characterized by gradual thyroid failure because of autoimmune destruction of the thyroid gland.
Images
Cytology FNA : (...) -
ankylosing spondylitis
17 August 2004Susceptibility
major histocompatibility complex (MHC) region
HLA B27
rs13202464 within the MHC region mainly represents the risk effect of HLA-B*27 variants (including HLA-B*2704, HLA-B*2705 and HLA-B*2715) (Chinese)
Locus 2q13 (IL1 cluster) (#15309690#)
EDIL3 and HAPLN1 at 5q14.3 (rs4552569) (bone formation and cartilage development)
ANO6 at 12q12 (rs17095830) (bone formation and cartilage development)
2p15 (rs10865331)
Reviews
Sims AM, Wordsworth BP, Brown MA. Genetic (...) -
Sjögren disease
24 March 2010primary Sjögren’s syndrome; Goujerot-Sjögren disease; Sjögren syndrome
Sjogren’s syndrome causes keratoconjunctivitis sicca and xerostomia. It can also cause other exocrine abnormalities such as vaginal dryness, bronchitis, and affect other organs.
Anti-SS-A (Ro) and anti-SS-B (La) antibodies
Anti-SS-A(Ro) antibodies are found in many autoimmune disorders, such as SLE, subacute cutaneous lupus, neonatal lupus, ANA negative lupus, Sjogren’s syndrome, primary biliary cirrhosis, chronic active (...) -
zymogen granules
19 June 2017 -
autoimmune polyglandular syndrome type 2
16 November 2007autoimmune polyglandular syndrome type II, APS2
-
type 1 diabetes
25 September 2003type I diabetes
-
autoimmune lymphoproliferative syndrome
6 April 2004ALPS, Canale-Smith syndrome
-
autoimmune polyglandular syndrome type 1
16 November 2007autoimmune polyglandular syndrome type I, APS1, APECED