salivary mucoepidermoid carcinoma
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Definition: The mucoepidermoid carcinoma is the most common malignant neoplasm observed in the major and minor salivary glands.
Synopsis
In children: #10964053#
Immunochemistry
cytokeratin+
mucin proteins expression (#15958852#)
- 71% for MUC1
- 21% for MUC2
- 79% for MUC4
- 68% for MUC5AC
Variants
oncocytic mucoepidermoid carcinoma (#18971778#)
Differential diagnosis
necrotizing sialometaplasia (NSM)
metastatic squamous carninoma (for high-grade MEC)
adenosquamous carcinoma
cystadenoma
cystadenocarcinoma
sebaceous carcinoma
clear cell tumors
- acinic cell carcinoma
- clear cell carcinoma
- metastatic renal cell carcinoma
oncocytic tumors
- oncocytoma
- concocytic carcinoma
- metastatic renal cell carcinoma
Cytogenetics
t(11;19)(q21;p13) translocation
Molecular biology
MECT1-MAML2 fusion gene by t(11;19)(q21;p13)
- fusion of the N-terminal CREB-binding domain of the cAMP coactivator TORC1 (a.k.a. MECT1 and WAMTP1) to the Notch coactivator MAML2.
The MECT1/MAML2 translocation is identified in a large proportion of mucoepidermoid carcinomas (MEC) of the salivary gland and is an emerging favorable prognosticator.
However, there are conflicting data on this translocation’s specificity, restriction to low/intermediate MEC, and strength as a prognosticator.
Grading: #11420454#, #9529011#
Grading parameters (#9529011#)
- intracystic component <20%
- neural invasion
- necrosis
- mitosis > 4 per 10 HPF
- anaplasia
See also
salivary tumors (salivary gland tumors)
References
A reappraisal of the MECT1/MAML2 translocation in salivary mucoepidermoid carcinomas. Seethala RR, Dacic S, Cieply K, Kelly LM, Nikiforova MN. Am J Surg Pathol. 2010 Aug;34(8):1106-21. PMID: #20588178#
Handra-Luca A, Lamas G, Bertrand JC, Fouret P. MUC1, MUC2, MUC4, and MUC5AC expression in salivary gland mucoepidermoid carcinoma: diagnostic and prognostic implications. Am J Surg Pathol. 2005 Jul;29(7):881-9. PMID: #15958852#
Guzzo M, Andreola S, Sirizzotti G, Cantu G. Mucoepidermoid carcinoma of the salivary glands: clinicopathologic review of 108 patients treated at the National Cancer Institute of Milan. Ann Surg Oncol. 2002 Aug;9(7):688-95. PMID: #12167584#
Brandwein MS, Ivanov K, Wallace DI, Hille JJ, Wang B, Fahmy A, Bodian C, Urken ML, Gnepp DR, Huvos A, Lumerman H, Mills SE. Mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading. Am J Surg Pathol. 2001 Jul;25(7):835-45. PMID: #11420454#
Goode RK, Auclair PL, Ellis GL. Mucoepidermoid carcinoma of the major salivary glands: clinical and histopathologic analysis of 234 cases with evaluation of grading criteria. Cancer. 1998 Apr 1;82(7):1217-24. PMID: #9529011#