Definition: Acute basophilic leukemia is rare type of acute myeloid leukemia.
Acute basophilic leukemia (ABL) can arise from chronic myelogenous leukemia with development of t(7;8)(q32;q13). (18328951)
Synopsis
Phenotype: cell stem origin basophilic precursor
Epidemiology: very rare but might be prominent in infants
Clinics:
- hyperhistaminemia syndrome
Cytology
major component of undifferentiated blasts
minor component of basophilic blasts
- blasts containing large granules reacting positively to toluidine blue staining
Prognosis
good response to standard therapy for chilhood ANLL
Cytogenetics
t(X;6)(p11;q23)
t(7;8)(q32;q13)
References
Pidala J, Pinilla-Ibarz J, Cualing HD. A case of acute basophilic leukemia arising from chronic myelogenous leukemia with development of t(7;8)(q32;q13). Cancer Genet Cytogenet. 2008 Apr 1;182(1):46-9. PMID: 18328951
Acute basophilic leukaemia and translocation t(X;6)(p11;q23) Dastugue N, Duchayne E, Kuhlein E, Rubie H, Demur C, Aurich J, Robert A, Sie P. Br J Haematol. 1997 Jul;98(1):170-6. PMID: 97376810
