T-cell lymphoblastic lymphomas (T-LBL) are rare disorders of immature T cells which predominantly involve the mediastinum. Their oncogenic pathways and prognostic variables are not clear.
T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LL) and are often thought to represent a spectrum of a single disease.
The malignant cells in T-ALL and T-LL are morphologically indistinguishable, and they share the expression of common cell surface antigens and cytogenetic characteristics. However, despite these similarities, differences in the clinical behavior of T-ALL and T-LL are observed.
Cytogenetics
translocations
- t(7;12)(q11.2;p13) (16211447)
- t(16;18)(p13.1;q21) (16211447)
- t(7;9) (q32;q34) (16211447)
- t(10;14)(q23; q11.2) (16211447)
- t(11;19) (q23;p?13.3) (16211447)
inv(2) (p11q13)
inv(9)(p11q12)
del(12)(p12)
del(16)(q22q22)
add (19)(p13.3)
del(9)(q11q22)
Molecular biology
gene rearrangements by chromosomal translocations between TCR subunit genes
and various partners
- MYC at 8q24
- TAL1 at 1p32
- LMO1 (RBTN1) at 11p15
- LMO2 (RBTN2) at 11p13
- TLX1 (HOX11) at 10q24
- LCK at 1p34-35
See also
Lymphomas
lymphoblastic lymphomas
acute lymphoblastic leukemias
- pre-B acute lymphoblastic leukemia
- pre-T acute lymphoblastic leukemia
