Molecular medicine began with Pauling’s seminal work, which recognized sickle-cell anemia as a molecular disease, and with Ingram’s demonstration of a specific chemical difference between the hemoglobins of normal and sickled human red blood cells.
Part I. Pathology of molecules
1. Pathology of DNA
DNA mutations
DNA replication
DNA repair
molecular checkpoints
polyglutamine diseases
2. Pathology of RNA
transcription and RNA synthesis
RNA processing, RNA splicing, RNA maturation
RNA transport
RNA translation
3. Pathology of proteins
protein lesions
protein folding
protein glycosylation
anomalies of proteolysis and proteasomal degradation
amyloidoses
prion diseases
4. Pathology of other molecules (metabolic diseases)
lipids
carbohydrates
vitamins
bile
heme
Part II. Pathology of cell signaling
5. External communication
cell-matrix signaling
cell-cell signaling
soluble factor-cell signaling
mechanosensitivity
chemosensitivity
6. Pathology of membrane receptors
Pathology of receptor tyrosine kinases (RTKs)
Pathology of receptor serine/threonine kinases
7. Pathology of intracellular signaling by cytoplasmic proteins
Pathology of Ras GTPases proteins family (ras, raf, rap, rho...)
8. Pathology of transcription factors
Pathology of NF-kappaB
9. Pathology of signaling pathways
hg signaling pathway (Hedgehog signaling pathway)
wnt signaling pathway (Wint signaling pathway)
wg signaling pathway (Wingless signaling pathway)
notch signaling pathway
NF-kappaB signaling pathway
patched signaling pathway
Part III. Pathology of cellular functions
10 - Growth
Pathology of cellular growth
Pathology of cellular cycle
Pathology of cellular division and mitosis
Pathology of meiosis
11. Pathology of cellular aging
12. Pathology of apoptosis and cellular death
13. Pathology of endocytosis
14. Pathology of membrane transport
15. Pathology of cellular trafficking
16. Pathology of exocytosis
Part IV. Pathology of molecular structures
17. Pathology of extracellular matrix components (connective tissue disorders)
18. Pathology of basal membranes
19. Pathology of intercellular junctions
Pathology of GAP junctions (connexins)
Pathology of desmosomes and hemidesmosomes
20. Pathology of the cytoplasmic membrane
21. Pathology of endoplasmic reticulum and Golgi apparatus
22. Pathology of vesicles and membranes
23. Pathology of cytoskeleton
24. Pathology of contractile apparatus
25. Pathology of filopodia
26. Pathology of mitochondria
Part V. Systemic molecular pathology
Molecular pathology of development
Molecular pathology of growth (overgrowth syndromes)
Pathology of aging
epithelial pathology
Journals
The Journal of Molecular Diagnostics
Molecular Pathology from Journal of CLinical Pathology (Mol Pathol)
Diagnostic Molecular Pathology (Diagn Mol Pathol)
Societies