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signaling pathways

Wednesday 11 June 2003

signaling network, signalling pathways, regulatory pathways, molecular pathways, signaling networks

Main signaling pathways

- ALK1 pathaway
- MAPK signaling pathways (ras/MAPK pathways)

  • Ras/MEK/ERK signaling pathway (RAS-ERK signaling pathway)
  • JNK/MAPK signaling pathway

- Notch signaling pathway
- WNT signaling pathway (catenins/APC signaling pathway)
- PI3K/PTEN/AKT signaling pathway (phosphoinositol-3-kinase/Akt signaling pathway)
- TSC/FRAP1 pathway (TSC/mTOR pathway)
- NF-kappaB signaling pathway
- PKA signaling pathway
- SHH-GLI signaling pathway (Hedgehog-Patched signaling pathway)
- TGF-beta signaling pathway
- ErbB signaling pathway
- receptor tyrosine kinase signaling pathways
- JAKs/STATs signaling pathways
- nuclear hormone signaling pathways
- FANC/BRCA1/BRCA2/ATM/NBS1 signaling pathway (BRCAs signaling pathway)
- Rb/E2F signaling pathway (P16(INK4A)-CDK4/6-RB pathway)
- endothelin receptor signaling pathway
- ARF-MDM2-P53 signaling pathway
- caspases pathway
- insulin signaling pathway
- cytokine signaling pathways

  • IL-5 signaling pathway

Databases

- PID Pathway Interaction Database
- KEGG pathway database
- Biocarta
- SPAD Signaling Pathway Database at Kyushu University
- Dynamic Signaling Maps

Websites

- Biosciences Pathway Central
- BioPathways at Covance

Softwares

- BioD, a visual language for describing, documenting and analyzing the functions of complex biological systems
- PathwayAssist, software tool for analysis, expansion and visualization of biological pathways
- GeneAssist Pathway Atlas

References

- P-Finder: Reconstruction of Signaling Networks from Protein-Protein Interactions and GO Annotations. Young-Rae Cho, Yanan Xin, Speegle G. IEEE/ACM Trans Comput Biol Bioinform. 2015 Mar-Apr;12(2):309-21. doi : 10.1109/TCBB.2014.2355216 PMID: 26357219

- Towards genome-scale signalling-network reconstructions. Hyduke DR, Palsson BO. Nat Rev Genet. 2010 Feb 23. PMID: 20177425

- Bhalla US. Models of cell signaling pathways. Curr Opin Genet Dev. 2004 Aug;14(4):375-81. PMID: 15261653

- Kabuyama Y, Resing KA, Ahn NG. Applying proteomics to signaling networks. Curr Opin Genet Dev. 2004 Oct;14(5):492-8. PMID: 15380239

- Pires-daSilva A, Sommer RJ. The evolution of signalling pathways in animal development. Nat Rev Genet. 2003 Jan;4(1):39-49. PMID: 12509752

- Tuveson DA, Fletcher JA. Signal transduction pathways in sarcoma as targets for therapeutic intervention. Curr Opin Oncol. 2001 Jul;13(4):249-55. PMID: 11429482