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mutation

Saturday 21 July 2007

DNA mutations ; gene mutation ; geneic mutations

WKP

Occurence

- somatic mutation
- constitutional mutation
- mutation in tumors

  • oncogenic mutation in tumor

Types

- point mutations
- in-frame mutations

- heteroduplexes mutations
- frameshift mutations
- polyglutamine mutations
- protective mutations
- mtDNA mutations
- epimutations
- synonymous mutations
- mice expressing designed gene mutations
- disease-predisposing mutations
- dynamic mutations

Fitness effects of mutations

- neutral mutations

- advantageous mutations

  • protective mutations
    • disease-protecting mutations
    • cancer-protecting mutations

- deleterious mutations

  • disease-predisposing mutations
    • mutations of disease genes
  • cancer-predisposing mutations
    • mutations of cancer genes
  • malformation-predisposing mutations
    • mutations of malformation genes

See also

- mutation databases
- mutation rate
- distribution of fitness effects (DFE) of mutations

References

- Baer CF, Miyamoto MM, Denver DR. Mutation rate variation in multicellular eukaryotes: causes and consequences. Nat Rev Genet. 2007 Aug;8(8):619-31. PMID: 17637734