Components
nodal cortex
- nodal follicular compartment
- germinal centers
- mantle (mantle cells)
- marginal zone
- perifollicular sinus
nodal paracortical compartment (nodal paracortex)
nodal sinusoidal compartment
Movement of the immune cell through the lymph node
Naive T cells enter the lymph node through high endothelial venules, which express the chemokine CCL21 (secondary lymphoid-tissue chemokine, or SLC).
Antigen-presenting cells, dendritic cells, and macrophages enter the lymph node through afferent lymphatics. Mature dendritic cells express CCR7, and macrophages express CCR2.
T cells and dendritic cells together localize in the T-cell zone in a CCR7-dependent manner. Antigen presentation results in the activation of T cells, and effector T cells exit the lymph node through the efferent lymphatics.
B cells are recruited to the follicles, where CXCL13 (B-cell chemoattractant 1 [BCA-1]) is present.
Pathology
nodal lesions
nodal lesional syndromes
nodal diseases
nodal tumors
- nodal lymphomas
Videos
Histology of the lymph node (by Washington Deceit)
Reticulin fibers in the lymph node (by Washington Deceit)
See also
nodal follicular compartment
nodal paracortical compartment (nodal paracortex)
nodal sinusoidal compartment
germinal centers
D2-40+ CD31+ perifollicular sinus around most of the follicular compartment
bcl-6-negative monocytoid B-cells
Epstein-Barr virus (EBV)
histiocyte-rich B-cell proliferations
prominence of the perifollicular sinus
reactive lymphadenitis
lymphatic
cytokines
lymph fluid
normal and altered germinal center reactions
sinus drainage
nodal T-cell lymphomas