CXCL13

CXCL13 can be produced by dendritic cells (DCs). (16189275)

For example, CSD granulomas in vivo contain CXCL13-producing DCs. (16189275)

Diagnostic use

 Expression of CXCL13 by neoplastic cells in angioimmunoblastic T-cell lymphoma (AITL)

• CXCL13 is a diagnostic marker providing evidence that AITL derives from follicular helper T cells. (16625095)

See also

 chemokines

• CXCs

References

 Expression of CXCL13 by neoplastic cells in angioimmunoblastic T-cell lymphoma (AITL): a new diagnostic marker providing evidence that AITL derives from follicular helper T cells. Dupuis J, Boye K, Martin N, Copie-Bergman C, Plonquet A, Fabiani B, Baglin AC, Haioun C, Delfau-Larue MH, Gaulard P. Am J Surg Pathol. 2006 Apr;30(4):490-4. PMID: 16625095

 Vermi W, Facchetti F, Riboldi E, Heine H, Scutera S, Stornello S, Ravarino D, Cappello P, Giovarelli M, Badolato R, Zucca M, Gentili F, Chilosi M, Doglioni C, Ponzi AN, Sozzani S, Musso T. Role of dendritic cell-derived CXCL13 in the pathogenesis of Bartonella henselae B-rich granuloma. Blood. 2006 Jan 15;107(2):454-62. PMID: 16189275

 Ansel, K. M.; Harris, R. B. S.; Cyster, J. G. : CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity. Immunity 16: 67-76, 2002. PubMed ID : 11825566

 Husson, H.; Freedman, A. S.; Cardoso, A. A.; Schultze, J.; Munoz, O.; Strola, G.; Kutok, J.; Carideo, E. G.; De Beaumont, R.; Caligaris-Cappio, F.; Ghia, P. : CXCL13 (BCA-1) is produced by follicular lymphoma cells: role in the accumulation of malignant B cells. Brit. J. Haemat. 119: 492-495, 2002. PubMed ID : 12406091

 Legler, D. F.; Loetscher, M.; Roos, R. S.; Clark-Lewis, I.; Baggiolini, M.; Moser, B. : B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. J. Exp. Med. 187: 655-660, 1998. PubMed ID : 9463416