lymph node

Components

 nodal cortex

• nodal follicular compartment
  • germinal centers
  • mantle ( mantle cells )
  • marginal zone
  • perifollicular sinus

 nodal paracortical compartment ( nodal paracortex )
 nodal sinusoidal compartment

Movement of the immune cell through the lymph node

Naive T cells enter the lymph node through high endothelial venules, which express the chemokine CCL21 (secondary lymphoid-tissue chemokine, or SLC).

Antigen-presenting cells, dendritic cells, and macrophages enter the lymph node through afferent lymphatics. Mature dendritic cells express CCR7, and macrophages express CCR2.

T cells and dendritic cells together localize in the T-cell zone in a CCR7-dependent manner. Antigen presentation results in the activation of T cells, and effector T cells exit the lymph node through the efferent lymphatics.

B cells are recruited to the follicles, where CXCL13 (B-cell chemoattractant 1 [BCA-1]) is present.

Pathology : nodal pathology / nodal histopathology

 nodal anomalies
 nodal lesional syndromes
 nodal diseases
 nodal tumors

• nodal lymphomas
  • B-cell lymphomas
  • T-cell lymphomas

Videos

 Histology of the lymph node (by Washington Deceit)

• http://www.youtube.com/v/8ngnKIyBA20

 Reticulin fibers in the lymph node (by Washington Deceit)

• http://www.youtube.com/v/gphYeMLNtCM

See also

 nodal follicular compartment
 nodal paracortical compartment ( nodal paracortex )
 nodal sinusoidal compartment
 germinal centers
 D2-40+ CD31+ perifollicular sinus around most of the follicular compartment
 bcl-6-negative monocytoid B-cells
 Epstein-Barr virus (EBV)
 histiocyte-rich B-cell proliferations
 prominence of the perifollicular sinus
 reactive lymphadenitis
 lymphatic
 cytokines
 lymph fluid
 normal and altered germinal center reactions
 sinus drainage
 nodal T-cell lymphomas

Open references

 Histopathology of the Lymph Nodes. Susan A. Elmore. 2007. doi : 10.1080/01926230600964722