WHO classification of lymphomas (2008)
The mature B-cell neoplasms (WHO 2008)
chronic lymphocytic leukemia/small lymphocytic lymphoma
B-cell prolymphocytic leukemia
splenic marginal zone B-cell lymphoma (SMZBCL)
hairy cell leukemia
splenic lymphoma/leukemia, unclassifiable
- splenic diffuse red pulp small B-cell lymphoma
- hairy cell leukemia variant
heavy chain diseases
- alpha heavy chain disease
- gammaheavy chain disease
- mu heavy chain disease
plasma cell myeloma
solitary plasmocytoma of the bone
extraosseous plasmocytoma
extranodal marginal zone B-cell lymphoma (extranodal MZBCL) (MALT lymphoma)
nodal marginal zone B-cell lymphoma (nodal MZBCL)
follicular lymphoma (follicular B-cell lymphoma, follicle centre cell lymphoma)
- pediatric type follicular lymphoma
primary cutaneous follicle centre cell lymphoma
mantle cell lymphoma
diffuse large B-cell lymphomas (DLBCL), not othrwise specified (NOS)
- T cell/histiocyte rich large B-cell lymphoma
- DLBCL with chronic inflammation
- EBV+ DLBCL of the elderly
lymphomatoid granulomatosis
primary mediastinal (thymic) large B-cell lymphoma
intravascular large B-cell lymphoma
primary cutaneous DLBCL, leg type
ALK+ large B-cell lymphoma
plasmablastic lymphoma
primary effusion lymphoma
large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease
Burkitt lymphoma
B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma
B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma
Hodgkin lymphoma
nodular lymphocyte-predominant Hodgkin lymphoma
classical Hodgkin lymphoma
- nodular sclerosis classical Hodgkin lymphoma
- lymphocyte-rich classical Hodgkin lymphoma
- mixed cellularity classical Hodgkin lymphoma
- lymphocyte-depleted classical Hodgkin lymphoma
The mature T-cell and NK-cell neoplasms (WHO 2008)
References
Staudt LM. Molecular diagnosis of the hematologic cancers. N Engl J Med. 2003 May 1;348(18):1777-85. PMID: 12724484
Küppers R. Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer 2005;5:251-262. PMID: 15803153
O’Neil J, Look AT. Mechanisms of transcription factor deregulation in lymphoid cell transformation. Oncogene 2007;26:6838-6849. PMID: 17934490