Human pathology

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HHV-8

human herpesvirus-8, KSHV, HHV8

Human herpesvirus-8 (HHV-8) is associated with several distinct lymphoproliferative disorders: primary effusion lymphoma, multicentric Castleman disease (MCD), MCD-associated plasmablastic lymphoma and HHV-8+, Epstein-Barr virus (EBV)+ germinotropic lymphoproliferative disorder.

Pathology

- Kaposi sarcoma
- HHV-8-associated lymphoproliferative disorders

  • HHV8-associated multicentric Castleman disease (MCD)
  • HHV8-associated multicentric Castleman disease-associated plasmablastic lymphoma
  • HHV8+ Epstein-Barr virus+ germinotropic lymphoproliferative disorder

References

- Seliem RM, Griffith RC, Harris NL, Beheshti J, Schiffman FJ, Longtine J, Kutok J, Ferry JA. HHV-8+, EBV+ multicentric plasmablastic microlymphoma in an HIV+ Man: the spectrum of HHV-8+ lymphoproliferative disorders expands. Am J Surg Pathol. 2007 Sep;31(9):1439-45. PMID: 17721201

Reviews

- Wang HW, Boshoff C. Linking Kaposi virus to cancer-associated cytokines. Trends Mol Med. 2005 Jul;11(7):309-12. PMID: 15967719

- Verschuren EW, Jones N, Evan GI. The cell cycle and how it is steered by Kaposi?s sarcoma-associated herpesvirus cyclin. J Gen Virol. 2004 Jun;85(Pt 6):1347-61. PMID: 15166416