HHV8-associated solid lymphoma
Primary effusion lymphoma (PEL) is a unique form of non-Hodgkin lymphoma (NHL) associated with Kaposi sarcoma-associated herpesvirus (KSHV; HHV-8) that displays a distinct constellation of clinical, morphologic, immunologic, and molecular characteristics. Rare KSHV-containing immunoblastic lymphomas occurring in solid tissues have been described. KSHV-positive solid lymphomas are extra-cavitary PELs.
Synopsis
immunoblastic/anaplastic phenotype
immunochemistry: CD45 positive; T cell antigen negative; CD30, EMA, CD138 positive; CD10, CD15, BCL6 negative
genotype
- 100% immunoglobulin genes rearranged
- no identifiable abnormalities in C-MYC, BCL6, BCL1, BCL
References
Chadburn A, Hyjek E, Mathew S, Cesarman E, Said J, Knowles DM. KSHV-positive solid lymphomas represent an extra-cavitary variant of primary effusion lymphoma. Am J Surg Pathol. 2004 Nov;28(11):1401-16. PMID: #15489644#
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