HHV8-associated lymphoma
Synopsis
sinusoidal infiltrate
large B-cells
possible anaplastic cellular morphology
strong positivity for KSHV/HHV8 latency-associated nuclear antigen
PCR analysis: KSHV/HHV8 infection
Molecular bioogy
B-cell lineage with immunoglobulin heavy and kappa light chain gene rearrangements
Differential diagnosis
anaplastic large cell lymphoma (ALCL)