Associations
human immunodeficiency virus (HIV)
Synopsis
fever
generalized lymphadenopathy
splenomegaly
multicentric Castleman disease (MCD) background
prominent proliferation of HHV-8+, EBV+, CD20, CD138, MUM1+, lambda dim+, Ig heavy chain plasmablasts and immunoblasts replacing some follicles
spleen
- replacement of occasional white pulp by the HHV-8+ EBV+ large lymphoid cells
bone marrow
- extensive hemophagocytosis
- hemophagocytic syndrome
MCD-associated plasmablastic lymphoproliferative disorder, with pathologic features intermediate between HHV-8+ plasmablastic microlymphoma, and HHV-8+ germinotropic lymphoproliferative disorder.
See also
multifocal plasmablastic microlymphoma
HHV-8+ germinotropic lymphoproliferative disorder
See also
Kaposi sarcoma
HHV8-associated lymphomas (HHV-8+ lymphoproliferative disorders)
- HHV8-associated primary effusion lymphoma
- HHV8-associated solid lymphoma
References
Seliem RM, Griffith RC, Harris NL, Beheshti J, Schiffman FJ, Longtine J, Kutok J, Ferry JA. HHV-8+, EBV+ multicentric plasmablastic microlymphoma in an HIV+ Man: the spectrum of HHV-8+ lymphoproliferative disorders expands. Am J Surg Pathol. 2007 Sep;31(9):1439-45. PMID: 17721201