Classification
clear cell renal cell carcinoma (and eosinophilic variants)
papillary renal cell carcinomas
- type I papillary renal cell carcinoma
- type II papillary renal cell carcinoma
chromophobe renal cell carcinoma
collecting duct renal carcinoma (collecting duct type renal cell carcinoma)
TFE3-associated renal cell carcinoma
TFEB-associated renal cell carcinoma
Variants
sarcomatoid renal cell carcinoma
- Can occur in all histologic subtypes of renal cell carcinoma
Predisposition
von Hippel-Lindau disease (renal clear cell carcinoma)
- VHL gene mutations at 3p26
MET germline mutations (papillary renal cell carcinoma)
hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC) (MIM.605839)
- mutations in the gene encoding fumarate hydratase (FH) (MIM.136850), an enzyme of the Krebs cycle
paraganglioma and early-onset renal cell cacinoma
- SDHB germline mutations at 1p36-p35 (MIM.185470) (14685938)
multicentric papillary renal cell carcinoma associated with renal adenomatosis
hyperparathyroidism-jaw tumor syndrome (papillary renal cell carcinoma)
Birt-Hogg-Dube syndrome (BHD)
References
Takahashi M, Teh BT, Kanayama HO. Elucidation of the molecular signatures of renal cell carcinoma by gene expression profiling. J Med Invest. 2006 Feb;53(1-2):9-19. PMID: 16537991
Takahashi M, Sugimura J, Yang X, Vogelzang N, Teh BS, Furge K, Teh BT. Gene expression profiling of renal cell carcinoma and its implications in diagnosis, prognosis, and therapeutics. Adv Cancer Res. 2003;89:157-81. PMID: 14587873
Reviews
Cohen HT, McGovern FJ. Renal-cell carcinoma. N Engl J Med. 2005 Dec 8;353(23):2477-90. PMID: 16339096
Pavlovich CP, Schmidt LS. Searching for the hereditary causes of renal-cell carcinoma. Nat Rev Cancer. 2004 May;4(5):381-93. PMID: 15122209
Dal Cin P. Genetics in renal cell carcinoma. Curr Opin Urol. 2003 Nov;13(6):463-6. PMID: 14560139
Linehan WM, Walther MM, Zbar B. The genetic basis of cancer of the kidney. J Urol. 2003 Dec;170(6 Pt 1):2163-72. PMID: 14634372
Bodmer D, van den Hurk W, van Groningen JJ, Eleveld MJ, Martens GJ, Weterman MA, van Kessel AG. Understanding familial and non-familial renal cell cancer. Hum Mol Genet. 2002 Oct 1;11(20):2489-98. PMID: 12351585