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sarcomatoid renal cell carcinoma

Sunday 21 January 2007

Definition: Sarcomatoid renal cell carcinoma (RCC) is a tumor exhibiting marked cytologic atypia and containing enlarged pleomorphic or malignant spindle cells reminiscent of a sarcoma.

Images

- Sarcomatoid chromophobe RCC. CK7 is negative in the sarcomatoid component

A sarcomatoid component in RCC is associated with a poor prognosis, with a median survival following diagnosis of less than 1 year reported in most studies.

A sarcomatoid component can occur in all histologic subtypes of RCC. Some reports indicate that sarcomatoid change more commonly occurs in chromophobe RCC compared with clear cell (conventional) RCC or papillary RCC.

References

- Dal Cin P, Sciot R, Van Poppel H, Balzarini P, Roskams T, Van den Berghe H. Chromosome changes in sarcomatoid renal carcinomas are different from those in renal cell carcinomas. Cancer Genet Cytogenet. 2002 Apr 1;134(1):38-40. PMID: 11996794