mycosis fungoides
Variants
folliculotropic mycosis fungoides (17721200)
Cytogénétique
Chromosome abnormalities, mostly complex karyotypes, are seen in about 50% of patients with MF/SS, and there have only been a few instances of recurrent rearrangements.
47% of abnormal karyotype by SKY/FISH (16382449)
- chromosome 10
- chromosome 6 (deletion)
- chromosome 3
- chromosome 7
- chromosome 9
- chromosome 17
- chromosome 19
- chromosome 1
- chromosome 12
- chromosome 8
- chromosome 11
- chromosome 13 (deletion)
recurrent breakpoints
pseudodicentric translocation between the short arms of chromosomes 8 - dic(17;8)(p11.2;p11.2) (16382449)
CGH
gains
- 1p36-pter gain
- 7 gain
- 9q34-qter gain
- 17q24-qter gain
- 19 gain
losses
- 2q36-qter loss
- 9p21 loss
- 17p loss
LOH (17895757)
See also
- Lymphomas
-
cutaneous tumors
- cutaneous T-cell lymphoma (CTCL)
- mycosis fungoides
- cutaneous T-cell lymphoma (CTCL)
References
Katona TM, O?malley DP, Cheng L, Hiatt KM, Wang M, Anagnostou JJ Jr, Billings SD, Smoller BR. Loss of Heterozygosity Analysis Identifies Genetic Abnormalities in Mycosis Fungoides and Specific Loci Associated With Disease Progression. Am J Surg Pathol. 2007 Oct;31(10):1552-1556. PMID: 17895757
Batista DA, Vonderheid EC, Hawkins A, Morsberger L, Long P, Murphy KM, Griffin CA. Multicolor fluorescence in situ hybridization (SKY) in mycosis fungoides and Sezary syndrome: search for recurrent chromosome abnormalities. Genes Chromosomes Cancer. 2006 Apr;45(4):383-91. PMID: 16382449
Prochazkova M, Chevret E, Mainhaguiet G, Sobotka J, Vergier B, Belaud-Rotureau MA, Beylot-Barry M, Merlio JP. Common chromosomal abnormalities in mycosis fungoides transformation. Genes Chromosomes Cancer. 2007 Jun 21; PMID: 17584911
Girardi M, Heald PW, Wilson LD. The pathogenesis of mycosis fungoides. N Engl J Med. 2004 May 6;350(19):1978-88. PMID: 15128898