lymphomas

PO

Digital cases (Examples)

 HPC:296 : Colonic MALT lymphoma
 HPC:302 : Mediastinal-pulmonary diffuse large B-cell lymphoma (DLBCL), EBV-associated
 HPC:305 : diffuse large B-cell lymphoma of the tonsil (DLBCL of the tonsil)

Subtypes

 B-cell lymphomas
 T-cell lymphomas

• T/NK lymphomas

WHO classification of lymphomas (2008)

The mature B-cell neoplasms (WHO 2008)

 chronic lymphocytic leukemia/small lymphocytic lymphoma
 B-cell prolymphocytic leukemia
 splenic marginal zone B-cell lymphoma (SMZBCL)
 hairy cell leukemia
 splenic lymphoma/leukemia, unclassifiable

• splenic diffuse red pulp small B-cell lymphoma
• hairy cell leukemia variant

 lymphoplasmacytic lymphoma

• Waldenstrom macroglobulinemia

 heavy chain diseases

• alpha heavy chain disease
• gammaheavy chain disease
• mu heavy chain disease

 plasma cell myeloma
 solitary plasmocytoma of the bone
 extraosseous plasmocytoma
 extranodal marginal zone B-cell lymphoma (extranodal MZBCL) (MALT lymphoma)
 nodal marginal zone B-cell lymphoma (nodal MZBCL)
 follicular lymphoma (follicular B-cell lymphoma, follicle centre cell lymphoma)

• pediatric type follicular lymphoma

 primary cutaneous follicle centre cell lymphoma
 mantle cell lymphoma
 diffuse large B-cell lymphomas (DLBCL), not othrwise specified (NOS)

• T cell/histiocyte rich large B-cell lymphoma
• DLBCL with chronic inflammation
• EBV+ DLBCL of the elderly

 lymphomatoid granulomatosis
 primary mediastinal (thymic) large B-cell lymphoma
 intravascular large B-cell lymphoma
 primary cutaneous DLBCL, leg type
 ALK+ large B-cell lymphoma
 plasmablastic lymphoma
 primary effusion lymphoma
 large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease
 Burkitt lymphoma
 B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma
 B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma

Hodgkin lymphoma

 nodular lymphocyte-predominant Hodgkin lymphoma
 classical Hodgkin lymphoma

• nodular sclerosis classical Hodgkin lymphoma
• lymphocyte-rich classical Hodgkin lymphoma
• mixed cellularity classical Hodgkin lymphoma
• lymphocyte-depleted classical Hodgkin lymphoma

The mature T-cell and NK-cell neoplasms (WHO 2008)

Diagnosis of lymphomas

 B-cell lymphomas

• nodular B-cell lymphomas
• diffuse B-cell lymphomas
  • low-grade B-cell lymphomas
    • small B-cell lymphomas

• • high-grade B-cell lymphomas
    • large B-cell lymphomas

 T-cell lymphomas

References

 Staudt LM. Molecular diagnosis of the hematologic cancers.
N Engl J Med. 2003 May 1;348(18):1777-85. PMID: 12724484

 Küppers R. Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer 2005;5:251-262. PMID: 15803153

 O’Neil J, Look AT. Mechanisms of transcription factor deregulation in lymphoid cell transformation. Oncogene 2007;26:6838-6849. PMID: 17934490