cutaneous T-cell lymphomas
Cutaneous T-cell lymphoma (CTCL) is a clonally derived lymphoproliferative disorder that preferentially involves the skin. The two major clinical expressions of CTCL, mycosis fungoides (MF) and Sézary syndrome (SS), have poorly understood pathogenesis.
Types
mycosis fungoides (MF)
Sezary syndrome (SS)
primary cutaneous CD30+ lymphoproliferative disorders
- primary cutaneous anaplastic large cell lymphoma
- lymphomatoid papulosis
- borderline lesions
subcutaneous panniculitis-like T-cell lymphoma
primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma
primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma
cutaneous gamma/delta T-cell lymphoma
Cytogénétique
Chromosome abnormalities, mostly complex karyotypes, are seen in about 50% of patients with MF/SS, and there have only been a few instances of recurrent rearrangements.
47% of abnormal karyotype by SKY/FISH (16382449)
- chromosome 10
- chromosome 6 (deletion)
- chromosome 3
- chromosome 7
- chromosome 9
- chromosome 17
- chromosome 19
- chromosome 1
- chromosome 12
- chromosome 8
- chromosome 11
- chromosome 13 (deletion)
recurrent breakpoints
pseudodicentric translocation between the short arms of chromosomes 8 - dic(17;8)(p11.2;p11.2) (16382449)
See also
References
Batista DA, Vonderheid EC, Hawkins A, Morsberger L, Long P, Murphy KM, Griffin CA. Multicolor fluorescence in situ hybridization (SKY) in mycosis fungoides and Sezary syndrome: search for recurrent chromosome abnormalities. Genes Chromosomes Cancer. 2006 Apr;45(4):383-91. PMID: 16382449