hypodermitis

WKP

PO

Examples

 Subcutaneous fat necrosis of newborn : lobular panniculitis with needle-shaped clefts in radial array

• https://twitter.com/JJSpeiserMD/status/793158471533338624

Digital cases

 JRC:10 : Weber-Christian disease.
 http://www.virtualpathology.leeds.ac.uk/slides/library/

Morphological types

 septal hypodermitis / septal panniculitis
 lobular hypodermitis / lobular panniculitis
 cytophagic histiocytic panniculitis
 neutrophilic panniculitis

Etiology by pattern

 septal hypodermitis / septal panniculitis

• erythema nodosum
• alpha-1-antitrypsin deficiency

 lobular hypodermitis / lobular panniculitis

• nodular vasculitis (erythema induratum)
• subcutaneous fat necrosis of newborn
• pancreatic fat necrosis
• lupus panniculitis
• physical and factitious panniculitis
• others

 cytophagic histiocytic panniculitis
 neutrophilic panniculitis

Etiology

 erythema nodosum

• subacute nodular migratory panniculitis/erythema nodosum migrans

 erythema induratum

• nodular vasculitis

 connective tissue disease panniculitis

• lupus erythematosus profundus (lupus panniculitis )
• morphea profunda/scleroderma panniculitis/eosinophilic fasciitis
• dermatomyositis
• connective tissue panniculitis

 lipoatrophy

• lipodystrophy
• localized lipoatrophy
  • involutional lipoatrophy
  • inflammatory lipoatrophy
    • lipophagic panniculitis/granulomatous lipoatrophy

 factitial panniculitis and traumatic panniculitis

• injection induced (steroids, insulin, narcotics, other drugs )
• sclerosing lipogranuloma
• blunt trauma

 cold panniculitis

• popside panniculitis
• equestrian panniculitis

 panniculitis of newborn of infants

• subcutaneous fat necrosis of the newborn
• sclerema neatorum

 drug-induced panniculitis

• direct effect
• systemic effect
  • post-steroid panniculitis
  • ciprofloxacin

 alpha1-antitrypsin deficiency-associated panniculitis
 calcifying panniculitis

• renal failure
• parathyroid disease

 pancreatic panniculitis
 gouty panniculitis

 panniculitis with cytophagic histiocytes

• cytophagic histiocytic panniculitis
• malignant histiocytosis (histiocytic sarcoma )
• sinus histiocytosis with lymphadenopathy (Rosai-Dorfman disease )
• T-cell lymphoma

 eosinophilic panniculitis

• parasitic infection
• Well syndrome
• incidental findings of eosinophils in other forms of panniculitis

 lipomembranous panniculitis
 non-infectious subcutaneous granulomatous disease

• granuloma annulare
• necrobiotic xanthogranuloma
• rheumatoid nodule
• sarcoidosis

 infectious panniculitis
 subcutaneous Whipple disease
 hemorrhagic panniculitis secondary to atheromatous emboli
 vasculitis involving the panniculus

• periarteritis nodosa

 Weber-Christian disease

See also

 hypodermis
 hypodermal anomalies