Colorectal cancer (CRC) is the second most common cause of cancer deaths in the United States.
Molecular biology
somatic mutions
- in APC gene
- in PPARG gene
Predisposition - Susceptibility
hereditary nonpolyposis colorectal cancer (HNPCC)
hereditary breast and colorectal cancer phenotype: 1100delC variant of the cell cycle checkpoint kinase CHEK2 gene was present in 18% of 55 families (12690581)
adenomatous colorectal polyposis
- APC mutations
- biallelic mutations in the base excision repair DNA glycosylase MYH
- ulcerative colitis-associated colorectal adenocarcinoma
Molecular biology
| 5q21-5q22 | APC |
| 8p21 | - |
CGH: 16145679
| losses | 4p | 8p | 17p | 18q | 14q | ||||
| gains | 1q | 7p | 8q | Ch.11 | 12p | 13q | 17q | Ch.19 | Ch.20 |
Videos
Colorectal adenocarcinoma
Colorectal adenocarcinoma
References
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de la Chapelle A. Genetic predisposition to colorectal cancer. Nat Rev Cancer. 2004 Oct;4(10):769-80. PMID: 15510158
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Kerr D. Clinical development of gene therapy for colorectal cancer. Nat Rev Cancer. 2003 Aug;3(8):615-22. PMID: 12894249
Lynch HT, de la Chapelle A. Hereditary colorectal cancer. N Engl J Med. 2003 Mar 6;348(10):919-32. PMID: 12621137
Rhodes JM, Campbell BJ. Inflammation and colorectal cancer: IBD-associated and sporadic cancer compared. Trends Mol Med. 2002 Jan;8(1):10-6. PMID: 11796261
Bustin SA, Jenkins PJ. The growth hormone-insulin-like growth factor-I axis and colorectal cancer. Trends Mol Med. 2001 Oct;7(10):447-54. PMID: 11597519