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Proteomics
Monday 20 October 2003
Definition: Proteomics is the study of the composition, structure, function and interactions of all the proteins in a cell.
Place the proteins
A central aim of cell biology is to find out where each protein functions in the cell.
In yeast
In 2003, 75% of the yeast proteome was known. In 2003, two large-scale studies of Saccharomyces cerevisiae, involving labelling over 4,000 proteins with GFP fluorescence or TAP (tandem affinity purification) tags, have made it possible to determine which proteins are made and how many copies per cell, and to track down their subcellular locations, such as the nucleus, nucleolus, mitochondria and the Golgi apparatus. The database, and strain collection information are accessible at http://yeastgfp.ucsf.edu.
Blogs
See also
high-throughput protein arrays
organelle proteomics
clinical proteomics
References
Lim MS, Elenitoba-Johnson KS. Proteomics in pathology research. Lab Invest. 2004 Oct;84(10):1227-44. PMID: 15311217
Chaurand P, Sanders ME, Jensen RA, Caprioli RM. Proteomics in diagnostic pathology: profiling and imaging proteins directly in tissue sections. Am J Pathol. 2004 Oct;165(4):1057-68. PMID: 15466373
Brunet S, Thibault P, Gagnon E, Kearney P, Bergeron JJ, Desjardins M. Organelle proteomics: looking at less to see more. Trends Cell Biol. 2003 Dec;13(12):629-38. PMID: 14624841
Baak JP, Path FR, Hermsen MA, Meijer G, Schmidt J, Janssen EA. Genomics and proteomics in cancer. Eur J Cancer. 2003 Jun;39(9):1199-215. PMID: 12763207
Wulfkuhle JD, Liotta LA, Petricoin EF. Proteomic applications for the early detection of cancer. Nat Rev Cancer. 2003 Apr;3(4):267-75. PMID: 12671665
McGregor E, Dunn MJ. Proteomics of heart disease.
Hum Mol Genet. 2003 Oct 15;12 Spec No 2:R135-44. PMID: 12928479
Bader GD, Heilbut A, Andrews B, Tyers M, Hughes T, Boone C. Functional genomics and proteomics: charting a multidimensional map of the yeast cell. Trends Cell Biol. 2003 Jul;13(7):344-56. PMID: 12837605
Brunet S, Thibault P, Gagnon E, Kearney P, Bergeron JJ, Desjardins M. Organelle proteomics: looking at less to see more. Trends Cell Biol. 2003 Dec;13(12):629-38. PMID: 14624841
Patterson SD, Aebersold RH. Proteomics: the first decade and beyond. Nat Genet. 2003 Mar;33 Suppl:311-23. PMID: 12610541
MacBeath G. Protein microarrays and proteomics. Nat Genet. 2002 Dec;32 Suppl:526-32. PMID: 12454649
