Podoplanin, which is immunoreactive to D2-40 antibody, is reportedly expressed in lymphatic vessels in non-neoplastic tissues, and also in vascular and non-vascular tumors.
The deduced 162-amino acid PDPN protein (podoplanin) contains a putative transmembrane region, a protein kinase A (MIM.176911) phosphorylation site, and a protein kinase C (MIM.176960) phosphorylation site.
Expression in tumors
lymphatic tumors
primary cutaneous carcinomas (17255777)
- sebaceous carcinomas
- squamous cell carcinomas
- porocarcinomas
- trichilemmal carcinomas
- skin adnexal carcinomas (NOS, not otherwise specified)
- majority of benign skin adnexal tumors
Diagnostic pathology
Podoplanin is a useful diagnostic marker for epithelioid hemangioendothelioma of the liver. (18084256)
Podoplanin is the only positive marker for chondrosarcoma. It can be used in the skull base chordoma vs chondrosarcoma differential diagnosis. (18820665)
Podoplanin is a better immunohistochemical marker for sarcomatoid mesothelioma than calretinin. (18162779)
Podoplanin is a highly sensitive and specific marker to distinguish primary skin adnexal carcinomas from adenocarcinomas metastatic to skin. (17255777)
Podoplanin (D2-40) is a marker for follicular dendritic cell tumors. (17951199)
References
Oakley GJ, Fuhrer K, Seethala RR. Brachyury, SOX-9, and podoplanin, new markers in the skull base chordoma vs chondrosarcoma differential: a tissue microarray-based comparative analysis. Mod Pathol. 2008 Sep 26. PMID: 18820665
Fujii T, Zen Y, Sato Y, Sasaki M, Enomae M, Minato H, Masuda S, Uehara T, Katsuyama T, Nakanuma Y. Podoplanin is a useful diagnostic marker for epithelioid hemangioendothelioma of the liver. Mod Pathol. 2008 Feb;21(2):125-30. PMID: 18084256
Podoplanin is a better immunohistochemical marker for sarcomatoid mesothelioma than calretinin. Padgett DM, Cathro HP, Wick MR, Mills SE. Am J Surg Pathol. 2008 Jan;32(1):123-7. PMID: 18162779
Podoplanin (D2-40) is a novel marker for follicular dendritic cell tumors. Yu H, Gibson JA, Pinkus GS, Hornick JL. Am J Clin Pathol. 2007 Nov;128(5):776-82. PMID: 17951199
Podoplanin is a highly sensitive and specific marker to distinguish primary skin adnexal carcinomas from adenocarcinomas metastatic to skin. Liang H, Wu H, Giorgadze TA, Sariya D, Bellucci KS, Veerappan R, Liegl B, Acs G, Elenitsas R, Shukla S, Youngberg GA, Coogan PS, Pasha T, Zhang PJ, Xu X. Am J Surg Pathol. 2007 Feb;31(2):304-10. PMID: 17255777
Agarwal B, Saxena R, Morimiya A, Mehrotra S, Badve S. Lymphangiogenesis does not occur in breast cancer. Am J Surg Pathol. 2005 Nov;29(11):1449-55. PMID: 16224211
Ordonez NG. D2-40 and podoplanin are highly specific and sensitive immunohistochemical markers of epithelioid malignant mesothelioma. Hum Pathol. 2005 Apr;36(4):372-80. PMID: 15891998
Nakano T, Nakashima Y, Yonemitsu Y, Sumiyoshi S, Chen YX, Akishima Y, Ishii T, Iida M, Sueishi K. Angiogenesis and lymphangiogenesis and expression of lymphangiogenic factors in the atherosclerotic intima of human coronary arteries. Hum Pathol. 2005 Apr;36(4):330-40. PMID: 15891993
Schmid K, Birner P, Gravenhorst V, End A, Geleff S. Prognostic value of lymphatic and blood vessel invasion in neuroendocrine tumors of the lung. Am J Surg Pathol. 2005 Mar;29(3):324-8. PMID: 15725800