CD30/TNFRSF8 is a type I transmembrane glycoprotein belonging to the TNF receptor superfamily.
The ligand for CD30 is CD30L (CD153, TNFSF8), a member of the TNF superfamily.
CD30 ligation by CD30L mediates pleiotropic effects, including cell proliferation, activation, differentiation and apoptosis.
The protein encoded by TNFRSF8 is a member of the TNF-receptor superfamily (TNFR superfamily).
CD30/TNFRSF8 is expressed by activated, but not by resting, T and B cells.
TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB.
CD30/TNFRSF8 is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.
Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Expression in normal cells
granulocytes
plasma cells
activated B-cells
activated T-cells
NK cells
Expression in diseases and tumors
infectious mononucleosis
lymphocytes infected with HIV, HTLV-1, EBV, HHV8 or HBV
Reed-Sternberg cells
anaplastic large cell lymphomas (ALCL) (90%)
lymphomatoid papulosis
peripheral T-cell lymphomas
primary effusion lymphoma
embryonal carcinoma of testis
Expression in tumors
classic Hodgkin lymphoma
anaplastic lymphoma
embryonal carcinoma
See also
CDs
References
CD30 Expression and Proliferative Fraction in Nontransformed Mycosis Fungoides. Edinger JT, Clark BZ, Pucevich BE, Geskin LJ, Swerdlow SH. Am J Surg Pathol. 2009 Oct 23. PMID: 19898220