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B-cell lymphomas

Classification

- Burkitt lymphoma
- Burkitt-like lymphoma
- mantle cell lymphoma
- marginal zone B-cell lymphoma (MZBCL) (MALT lymphoma)
- small lymphocytic lymphoma (SLL)
- diffuse large B-cell lymphomas (DLBC)
- lymphoplasmacytic lymphoma (Waldenstrom macroglobulinemia)
- intravascular large B-cell lymphoma
- follicular B-cell lymphoma (follicle centre cell lymphoma)

Localization

- nodal lymphomas
- extra-nodal lymphomas

Cytogenetics

Chromosomal translocations involving the immunoglobulin loci are a hallmark of many types of B-cell lymphoma. Other factors, however, also have important roles in the pathogenesis of B-cell malignancies.

Most B-cell lymphomas depend on the expression of a B-cell receptor (BCR) for survival, and in several B-cell malignancies antigen activation of lymphoma cells through BCR signalling seems to be an important factor for lymphoma pathogenesis.

- 1q12-22 rearrangements (12378526)

  • Abnormalities of chromosome arm 1q have frequently been reported in B-cell lymphomas and correlated with poor outcome.
  • Five genes mapped to this region (BCL9, MUC1, FCGR2B, IRTA1, and RTA2) have been shown to be deregulated by juxtaposition with the IG genes.
  • Other anomalies of the 1q21-22 region are not involved in translocations with the IG genes.
  • 1q12-22 breaks
  • dup(1)(q12-21q32)
  • trp(1)(q12q32)

See also

- Leukemias
- Lymphomas
- plasma cell neoplasms (plasmocytic tumors)

Reviews

- Kuppers R. Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer. 2005 Apr;5(4):251-262. PMID: 15803153

- Ramsay M. Gene expression profiling to predict lymphoma outcome. Trends Mol Med. 2002 Apr;8(4):159. PMID: 11927271

- Arber DA. Molecular diagnostic approach to non-Hodgkin’s lymphoma. J Mol Diagn. 2000 Nov;2(4):178-90. PMID: 11232108

- Staudt LM. Molecular diagnosis of the hematologic cancers. N Engl J Med. 2003 May 1;348(18):1777-85. PMID: 12724484

- Küppers R. Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer 2005;5:251-262. PMID: 15803153

- O’Neil J, Look AT. Mechanisms of transcription factor deregulation in lymphoid cell transformation. Oncogene 2007;26:6838-6849. PMID: 17934490

References

- Itoyama T, Nanjungud G, Chen W, Dyomin VG, Teruya-Feldstein J, Jhanwar SC, Zelenetz AD, Chaganti RS. Molecular cytogenetic analysis of genomic instability at the 1q12-22 chromosomal site in B-cell non-Hodgkin lymphoma. Genes Chromosomes Cancer. 2002 Dec;35(4):318-28. PMID: 12378526