salivary mucoepidermoid carcinoma
Image Gallery
Mucoepidermoid carcinoma is the most common malignant neoplasm observed in the major and minor salivary glands.
Synopsis
In children: 10964053
Immunochemistry
cytokeratin+
mucin proteins expression (15958852)
Differential diagnosis
necrotizing sialometaplasia (NSM)
metastatic squamous carninoma (for high-grade MEC)
adenosquamous carcinoma
cystadenoma
cystadenocarcinoma
sebaceous carcinoma
clear cell tumors
- acinic cell carcinoma
- clear cell carcinoma
- metastatic renal cell carcinoma
oncocytic tumors
- oncocytoma
- concocytic carcinoma
- metastatic renal cell carcinoma
Cytogenetics
t(11;19)(q21;p13) translocation
Molecular biology
TORC1-MAML2 fusion gene by t(11;19)(q21;p13)
- fusion of the N-terminal CREB-binding domain of the cAMP coactivator TORC1 (a.k.a. MECT1 and WAMTP1) to the Notch coactivator MAML2.
Grading parameters (9529011)
- intracystic component <20%
- neural invasion
- necrosis
- mitosis > 4 per 10 HPF
- anaplasia
See also
salivary tumors (salivary gland tumors)
References
Handra-Luca A, Lamas G, Bertrand JC, Fouret P. MUC1, MUC2, MUC4, and MUC5AC expression in salivary gland mucoepidermoid carcinoma: diagnostic and prognostic implications. Am J Surg Pathol. 2005 Jul;29(7):881-9. PMID: 15958852
Guzzo M, Andreola S, Sirizzotti G, Cantu G. Mucoepidermoid carcinoma of the salivary glands: clinicopathologic review of 108 patients treated at the National Cancer Institute of Milan. Ann Surg Oncol. 2002 Aug;9(7):688-95. PMID: 12167584
Brandwein MS, Ivanov K, Wallace DI, Hille JJ, Wang B, Fahmy A, Bodian C, Urken ML, Gnepp DR, Huvos A, Lumerman H, Mills SE. Mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading. Am J Surg Pathol. 2001 Jul;25(7):835-45. PMID: 11420454
Goode RK, Auclair PL, Ellis GL. Mucoepidermoid carcinoma of the major salivary glands: clinical and histopathologic analysis of 234 cases with evaluation of grading criteria. Cancer. 1998 Apr 1;82(7):1217-24. PMID: 9529011