Overexpressed in tumors

Articles

• GATA3
  24 May 2005

  GATA-3
  PO
  Definition: GATA3 is a zinc-finger transcription factor (ZFNs), which is expressed in various normal and neoplastic tissues.
  GATA3 is a transcription factor important in the differentiation of breast epithelia, urothelia, and subsets of T-lymphocytes.
  It has been suggested useful in the evaluation of mammary or urothelial origin or metastatic carcinomas. GATA3 is a useful marker in characterization not only mammary carcinomas and urothelial carcinoma but also for renal tumors (...)

• PRAME
  14 juin 2007

  PRAME is a gene encoding an antigen recognized on a human melanoma by cytolytic T cells.
  Human tumor antigens recognized by autologous cytolytic T lymphocytes (CTLs) include 3 classes of proteins : those expressed in tumors but not in normal tissues other than placenta or testis (like MAGE1 ; MIM.300016) ; differentiation antigens expressed in melanocytes or melanomas (like melan-A ; MIM.605513) ; and antigens resulting from point mutations in ubiquitously expressed genes (like MUM1 ; (...)

• WSB1
  1 May 2007

  SWIP1

• AKT2
  2 February 2007

  Definition: AKT2 (MIM.164731) is the isoform of AKT 1 and is enriched in insulin-responsive tissues and has been implicated in the metabolic actions of the hormone.
  Pathology
  An activating mutation of AKT2 and human hypoglycemia. (#21979934#)
  AKT2 mutations and/or amplification in tumors ovarian carcinomas (#16839745#, #16721043#) pancreatic carcinomas (#14735903#) mammary carcinomas (#12032855#) embryonal rhabdomyosarcoma (#16790082#)
  See also
  AKTs
  References
  An activating (...)

• MYB
  3 September 2007

  V-MYB AVIAN MYELOBLASTOSIS VIRAL ONCOGENE HOMOLOG
  Pathology
  MYB overexpression in colorectal cancer (CRC) is a prognostic indicator for poor survival.
  MYB duplication by dup(6)(q22-q23) in acute lymphoblastic leukemia (ALL)
  MYB-GATA1 fusion gene in acute basophilic leukemia (#21474671#)
  MYB-NFIB fusion gene in cystic carcinoma (ACC) mammary adenoid cystic carcinoma (MACC) salivary adenoid cystic carcinoma (MACC)
  Open References
  Identification of a transforming MYB-GATA1 fusion (...)

• KIF14
  6 September 2007

  KIF14 is a member of the kinesin superfamily of microtubule-associated motors (KIFs) that play important roles in intracellular transport and cell division.
  Pathology
  located in 1q32.1 amplification (62%) (positively associated with 6p gain and maybe MYCN gain) (#17099872#)
  KIF14 (kinesin family member 14) is an overexpressed candidate oncogene in the 1q31.3-1q32.1 minimal region of genomic gain in breast cancer cell lines.
  KIF14 overexpression is a negative predictor of grade and (...)

• COL4A2
  6 September 2007

  Pathology
  COL4A2 is overexpressed in glioblastoma multiforme (#17002787#)
  References
  Ruano Y, Mollejo M, Ribalta T, Fiano C, Camacho FI, Gomez E, de Lope AR, Hernandez-Moneo JL, Martinez P, Melendez B. Identification of novel candidate target genes in amplicons of Glioblastoma multiforme tumors detected by expression and CGH microarray profiling. Mol Cancer. 2006 Sep 26;5:39. PMID: (...)

• STIM2
  6 September 2007

  STIM2 is an inhibitor of STIM1 (MIM.605921)-mediated store-operated Ca(2+) (SOC) entry.
  Pathology
  STIM2 is overexpressed in glioblastoma multiforme (#17002787#)
  References
  Ruano Y, Mollejo M, Ribalta T, Fiano C, Camacho FI, Gomez E, de Lope AR, Hernandez-Moneo JL, Martinez P, Melendez B. Identification of novel candidate target genes in amplicons of Glioblastoma multiforme tumors detected by expression and CGH microarray profiling. Mol Cancer. 2006 Sep 26;5:39. PMID: (...)

• IRX2
  11 September 2007

  IRX2 is a member of the Iroquois homeobox gene family IRXs. Members of IRXs family appear to play multiple roles during pattern formation of vertebrate embryos.
  Pathology
  Copy number gains and high-level amplifications of the short arm of chromosome 5 are frequently observed in soft tissue sarcomas.
  amplified and overexpressed in MPNST (#16752383#)
  See also
  TRIO
  NKD2 (overexpressed in MPNSTs)
  References
  Adamowicz M, Radlwimmer B, Rieker RJ, Mertens D, Schwarzbach M, Schraml P, (...)

• PRDM16
  3 September 2007

  MEL1

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