Consumptive hypothyroidism is due to a vascular tumor expressing type 3 iodothyronine deiodinase.
The inactivation rate of thyroid hormone by D3 in tumors, as vascular tumors, can stress the secretory capacity even of the TSH-stimulated normal adult thyroid gland.
References
Balazs AE, Athanassaki I, Gunn SK, Tatevian N, Huang SA, Haymond MW, Karaviti LP. Rapid resolution of consumptive hypothyroidism in a child with hepatic hemangioendothelioma following liver transplantation. Ann Clin (...)
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