t(11;19)(q21;p13)
salivary mucoepidermoid carcinoma
salivary Warthin tumor
cutaneous clear cell hidradenoma
Molecular biology
TORC1-MAML2 fusion gene by t(11;19)(q21;p13)
- fusion of the N-terminal CREB-binding domain of the cAMP coactivator TORC1 (a.k.a. MECT1 and WAMTP1) to the Notch coactivator MAML2.
See also
References
Behboudi A, Winnes M, Gorunova L, van den Oord JJ, Mertens F, Enlund F, Stenman G. Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)?associated TORC1-MAML2 gene fusion. Genes Chromosomes Cancer. 2005 Jun;43(2):202-5. PMID: 15729701
Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O?Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, Kaye FJ. t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. Nat Genet. 2003 Feb;33(2):208-13. PMID: 12539049
El-Naggar AK, Lovell M, Killary AM, Clayman GL, Batsakis JG. A mucoepidermoid carcinoma of minor salivary gland with t(11;19)(q21;p13.1) as the only karyotypic abnormality. Cancer Genet Cytogenet. 1996 Mar;87(1):29-33. PMID: 8646736