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clear cell hidradenoma

Friday 9 September 2005

clear cell variants of cutaneous hidradenomas, clear cell cutaneous hidradenoma ; nodular hidradenoma

PO

Definition : Clear cell hidradenoma is a benign adnexal sweat gland tumor.

See also : hidradenoma

Images

- Clear cell hidradenoma

Synopsis

- benign dermal nodule / benign cutaneous nodule
- eccrine derivation / apocrine gland derivation
- biphasic cellular population

- dermal nodule with ducts
- cuboidal cells with pink cytoplasm
- clear cell degeneration
- halinized stroma

Molecular biology

- TORC1-MAML2 fusion gene by t(11;19)(q21;p13)

  • fusion of the N-terminal CREB-binding domain of the cAMP coactivator TORC1 (a.k.a. MECT1 and WAMTP1) to the Notch coactivator MAML2.

See also

- dermal tumors

References

- Winnes M, Molne L, Suurkula M, Andren Y, Persson F, Enlund F, Stenman G. Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas. Genes Chromosomes Cancer. 2007 Jun;46(6):559-63. PMID: 17334997