Home > E. Pathology by systems > Skin > clear cell hidradenoma
clear cell hidradenoma
Friday 9 September 2005
clear cell variants of cutaneous hidradenomas, clear cell cutaneous hidradenoma ; nodular hidradenoma
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Definition : Clear cell hidradenoma is a benign adnexal sweat gland tumor.
See also : hidradenoma
Images
Clear cell hidradenoma
- https://twitter.com/Patholwalker/status/961473938483105792
- https://twitter.com/RyanHickMD/status/664835582158336001
- https://twitter.com/JJSpeiserMD/status/740947872749867008
- https://twitter.com/drmalaybajpai/status/849881029791719424
- https://twitter.com/Patholwalker/status/1563816695633829888
- https://twitter.com/Patholwalker/status/1556206604009472002
- https://twitter.com/SGottesmanMD/status/785932940635213824
- https://twitter.com/Andy_pathology/status/1068014563503747072
- https://twitter.com/WebPathology/status/519228103130767361
Synopsis
benign dermal nodule / benign cutaneous nodule
eccrine derivation / apocrine gland derivation
biphasic cellular population
- (1) round cells , fusiform cells , or polygonal cells with vesicular nuclei and eosinophilic cytoplasm
- (2) clear cells with clear cytoplasm and often eccentrically located nuclei
dermal nodule with ducts
cuboidal cells with pink cytoplasm
clear cell degeneration
halinized stroma
Molecular biology
TORC1-MAML2 fusion gene by t(11;19)(q21;p13)
- fusion of the N-terminal CREB-binding domain of the cAMP coactivator TORC1 (a.k.a. MECT1 and WAMTP1) to the Notch coactivator MAML2.
See also
dermal tumors
- dermal clear cell tumors
References
Winnes M, Molne L, Suurkula M, Andren Y, Persson F, Enlund F, Stenman G. Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas. Genes Chromosomes Cancer. 2007 Jun;46(6):559-63. PMID: 17334997
