pulmonary veno-occlusive disease
pulmonary venoocclusive disease
Synopsis
veinous intimal fibrosis
Etiology
familial pulmonary veno-occlusive disease (7129408)
post-chemotherapy
- bleomycin (6199283)
Associations
pulmonary arterial occlusive disease (arterial intimal fibrosis) (4043952)
Ultrastructure (6341208)
occluded pulmonary veins
- intact endothelial cells
- haphazard proliferation of collagen fibrils and smooth muscle cells
alveolar capillaries
- thickening of the endothelial cell basement membrane
- increase in the number of cytoplasmic processes of pericytes
- electron-dense deposits located within the thickened basement membrane (considered to represent disintegrating extravasated erythrocytes rather than immune complexes)
References
Carrington CB, Liebow AA. Pulmonary veno-occlusive disease. Hum Pathol. 1970 Jun;1(2):322-4. PMID: 5521729