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pulmonary arterial occlusive disease

pulmonary arterial occlusive vascular disease

Friday 12 March 2004

Post-chemotherapy disorder

Etiology

- chemotherapy

Synopsis

Small pulmonary arteries

- diffuse medial hypertrophy
- diffuse peripheral muscularization
- very extensive concentric intimal fibrosis
- focal eccentric fibrosis evolving from organizing thrombi
- pulmonary veins normal

References

- Bentur L, Cullinane C, Wilson P, Greenberg M, O’Brodovich H, Silver MM. Fatal pulmonary arterial occlusive vascular disease following chemotherapy in a 9-month-old infant. Hum Pathol. 1991 Dec;22(12):1295-8. PMID: 1748437