pre-eclampsia
Preeclampsia is a common, pregnancy-specific disorder characterized by reduced placental perfusion, endothelial dysfunction, elevated blood pressure, and proteinuria.
The pathogenesis of this heterogeneous disorder is incompletely understood, but it has a familial component, which suggests that one or more common alleles may act as susceptibility genes.
Susceptibility loci
2p25 (12474145)
9p13 (12474145)
Videos
Eclampsia in kidneys (by Washington Deceit)
See also
eclampsia
References
Walsh SW. Obesity: a risk factor for preeclampsia. Trends Endocrinol Metab. 2007 Dec;18(10):365-70. PMID: 18023357
Vatish M, Randeva HS, Grammatopoulos DK. Hormonal regulation of placental nitric oxide and pathogenesis of pre-eclampsia. Trends Mol Med. 2006 May;12(5):223-33. PMID: 16616640