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Home > E. Pathology by systems > Reproductive system > Female genital system > pre-eclampsia


Monday 6 October 2003



Definition : Preeclampsia is a common, pregnancy-specific disorder characterized by reduced placental perfusion, endothelial dysfunction, elevated blood pressure, and proteinuria.

The pathogenesis of this heterogeneous disorder is incompletely understood, but it has a familial component, which suggests that one or more common alleles may act as susceptibility genes.

Susceptibility loci

- 2p25 (12474145)
- 9p13 (12474145)

See also

- eclampsia


- Walsh SW. Obesity: a risk factor for preeclampsia. Trends Endocrinol Metab. 2007 Dec;18(10):365-70. PMID: 18023357

- Vatish M, Randeva HS, Grammatopoulos DK. Hormonal regulation of placental nitric oxide and pathogenesis of pre-eclampsia. Trends Mol Med. 2006 May;12(5):223-33. PMID: 16616640