Humpath.com - Human pathology

Home > Technical section > Biology > Molecular biology > Population genetics > allele

allele

Friday 30 September 2005

Allelic frequencies

Allelic frequencies change in populations owing to two factors: natural selection, which is the result of population variation among individual genotypes in their probabilities of survival and/or reproduction, and random genetic drift, which is due to a finite number of individuals participating in the formation of the next generation.

Both natural selection and genetic drift can ultimately lead to the elimination or fixation of a particular allele.

In the presence of mutation and in the absence of selection (that is, under neutral conditions), the rate of neutral evolution of a finite population is equal to the reciprocal of the mutation rate.