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Home > E. Pathology by systems > Digestive system > Liver > giant cell transformation

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giant cell transformation

Giant cell transformation of hepatocytes in cholestasis Giant cell transformation. Giant multinucleated hepatocytes

Etiology:

- viral hepatitis

- bacterial hepatitis

- parasitic hepatitis (protozoan hepatitis)

  • toxoplasmosis hepatitis

- Cholestasis

- chromosomal anomalies

- metabolic diseases

  • alpha-1-antitrypsin deficiency
  • galactosemia
  • Niemann-Pick diseases
  • Gaucher diseases
  • mucolipidoses
  • cerebrohepatorenal syndrome (Zellweger syndrome)
  • acute tyrosinemia
  • some mitochondriopathies
  • some peroxysomopathies

- autoimmune diseases (immunohemolytic diseases)
- autoimmune hemolytic anemia (GCHAIHA)

- cardiovascuar diseases

  • endocardial cushion defect
  • anomalous pulmonary venous return

- neonatal hemochromatosis (fetal massive hepatic necrosis)

Associations

- neonatal hemochromatosis (idiopathic iron storage syndrome)
- Arnold-Chiari malformation

See also

- neonatal hepatitis
- syncitial cells