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CMV hepatitis
Wednesday 8 December 2004
Definition: CMV is the most important cause of opportunistic hepatitis in immunocompromised patients. 20% of patients with liver allograft develop CMV hepatitis.
Images
CMV inclusion in a portal space
Synopsis
cytomegalic cytopathic effects
- enlarged cells
- cytomegalic nuclear inclusions
- large, glassy masses in the nucleus, separated by a clear halo from the irregularly thickened nuclear membrane
- cytomegalic cytoplasmic inclusions
- basophilic or amphophilic granules of various size
- inclusion-bearing cells maybe encircled by a cluster of neutrophils
+/- confluent foci of hepatocellular necrosis
unusual massive hepatic necrosis
Three clinicopathological patterns
mononucleosis-like disease
See also
cytomegalovirus
CMV infections
viral hepatitis
Hepatitis
Videos
Congenital CMV disease by Washington Deceit
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References
Theise ND, Conn M, Thung SN. Localization of cytomegalovirus antigens in liver allografts over time. Hum Pathol. 1993 Jan;24(1):103-8. PMID: 8380273
