endometrial stromal sarcoma
Immunochemistry
SMM-HC+ (smooth muscle myosin heavy chain)
CD10+
calponin+
Cytogenetics
t(3;6)(q29;p21.1) (14580778)
t(7;17)(p15;q21) (JAZF1-JJAZ1 fusion gene)
t(10;17)(q22;p13) (14529693)
t(X;17)(p11:q23)
Molecular biology
fusion genes between JAZF1 at 7p15 and JJAZ1 at 17q21 by t(7;17)(p15;q21) (12850374, 11371647)
Differential diagnosis
endometrial stromal tumors
- benign stromal nodule
- undifferentiated endometrial sarcoma
uterine smooth muscle tumors
- cellular uterine leiomyoma
- uterine leiomosarcoma