uterine leiomyoma

See also : uterine smooth muscle tumors

Images

 atypical leiomyoma of uterus ( symplastic leiomyoma )

• https://twitter.com/mariaramir/status/728719369405075458

 uterine hydropic leiomyoma

• https://twitter.com/Patholwalker/status/1511995253783670791

See also

 leiomyomas

Epidemiology

Uterine leiomyoma occurs in about 20-30% of women over the age of 30, and is the most frequent benign tumor in gynecology.

Molecular forms

 FH-associated uterine leiomyoma

Cytogenetics

Cytogenetic analysis of uterine leiomyomata (UL) shows that about 40% of these benign tumors have simple, clonal chromosomal rearrangements.

 near-diploid karyotypes with del(1)(p11p36) (16320247)

• often associated with other aberrations, particularly loss of chromosomes 19 (19-) and/or 22 (22-)
• cellular UL
• hypercellularity and nuclear atypia

 1q42 rearrangement (FH, fumarate hydratase) (15334541, 12419594)

 10q22

• t(10;17) disrupts the histone acetyltransferase MORF (10q22) (monocytic leukemia zinc finger protein-related factor or MYST4). (15313893)

LOH and deletions

 del(1)(p11p36) (16320247)

 1q42 LOH and 1q42 deletions (FH, fumarate hydratase) (15334541, 12419594)

 7p15 LOH (15605361)

 7p22

• 7q22 deletion
• 7q22 LOH (9%-34%) ((15605361, 10549262, 9869453)

 7q LOH (9%) (10484989, 9869453)

 12q14 LOH (HMGA2)
 15q26 LOH (15605361)

Molecular biology

 allelotyping: 9869453
 transcriptional profiling: 15101043

Variants

 cellular uterine leiomyoma

References

 Wang T, Zhang X, Obijuru L, Laser J, Aris V, Lee P, Mittal K, Soteropoulos P, Wei JJ. A micro-RNA signature associated with race, tumor size, and target gene activity in human uterine leiomyomas. Genes Chromosomes Cancer. 2007 Apr;46(4):336-47. PMID: 17243163

 Quade BJ, Wang TY, Sornberger K, Dal Cin P, Mutter GL, Morton CC. Molecular pathogenesis of uterine smooth muscle tumors from transcriptional profiling. Genes Chromosomes Cancer. 2004 Jun;40(2):97-108. PMID: 15101043

 Dal Cin P, Morton CC. 1q42 approximately q44 is rarely cytogenetically involved in sporadic uterine leiomyomata. Cancer Genet Cytogenet. 2002 Oct 1;138(1):92-3. PMID: 12419594